ADMA and renal endothelial dysfunction: de effects of ARB and/or statins in hypertensive patients with mild renal insufficiency

Recruiting

Conditions: deterioration of renal function
renal dysfunction
10038430
10057166

Registration Number: NL-OMON32808

Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 69

Inclusion Criteria

o Hypertension
(Office blood pressure >140 and/or >90 mmHg or ABPM blood pressure:
>125 and/or >80 mmHg)
o Age: 18-75 jaar
o Creatinin clearance of 60-90 mL/min
(Cockcroft-Gault formula)
o Renal angiography indicated, based on the following criteria:
- Refractory hypertension
- Accelerating or malignant hypertension
- Elevating serum creatinin after an ACE-inhibitor or ARB
- Kidney size < 8 cm measured by ultrasound
- Unexplained hypokalemia
- Abdominal or
renal souffle
- Manifestations of atherosclerosis
elsewhere
- *Flash* oedema

Exclusion Criteria

o Primary kidney diseases or urological complaints
o Diabetes Mellitus
o Chronic inflammatory diseases
o Recent infections (< 3 weeks)
o Unilateral or bilateral renal artery stenosis
o Fibromuscular dysplasia (FMD)
o Contraindication for ARB or statin
o Use of > 4 units alcohol a day

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Basal renal perfusion, fractional change in renal perfusion after intrarenal<br /><br>L-NMMA infusion, arterial en venous ADMA, SDMA (symmetric dimethylarginine) and<br /><br>L-arginine concentrations and renal elimination of systemic ADMA, SDMA and<br /><br>L-arginine</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Microalbuminuria, creatinin clearance, blood pressure, plasma LDL (low density<br /><br>lipoproteins), HDL (high density lipoproteins), triglycerides and total<br /><br>cholesterol concentrations</p><br>