Study of Effects of native renal Artery denervation in Post TRANSPLANT Hypertensio

Completed

• Conditions: Renal transplantation; Urological and Genital Diseases

• Registration Number: ISRCTN35753246
• Lead Sponsor: HS Greater Glasgow and Clyde (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-05-09
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Patients aged 18?85 years, either sex, with a clinic systolic blood pressure of 140 mmHg or more, despite compliance with two or more antihypertensive drugs, are eligible for inclusion
2. Patients should be >12 months post renal transplantation with no evidence of rejection in past 3 months and doses of immunosuppression should be stable for >6 weeks prior to study entry

Exclusion Criteria

1. Inability to give informed consent
2. Contraindications to MRI imaging (pacemaker, extreme claustrophobia)
3. Pregnancy and breastfeeding
4. Impaired transplant kidney function (estimated glomerular filtration rate [GFR] <30 ml/min)
5. Known secondary cause of hypertension other than renal disease (e.g. Conn's syndrome, Phaeochromocytoma etc)

Study & Design

• Study Type: Interventional
• Study Design: Not specified