Renal Nerve Stimulation and renal Denervation in Patients with sympathetic Ventricular Arrhytmias.

Recruiting

Conditions: Patients with CPVT or certain types of long QT syndrome or ARVC.

Registration Number: NL-OMON24558

Lead Sponsor: Isala, Zwolle

Brief Summary: /A

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Patients with recurrent sympathetically driven ventricular arrhythmia despite optimal pharmacological therapy. Patients should be diagnosed with CPVT and certain types of long QT syndrome, ARVC, HCM, DCM and ICM. Eligible patients will be in the age category of 18-85 year.

Exclusion Criteria

Contraindication to anticoagulation therapy or heparin.
Previous selective cardiac sympathetic denervation or previous renal denervation procedure.
Acute coronary syndrome, cardiac surgery, PCI or stroke within 3 months prior to enrollment Untreated hypothyroidism or hyperthyroidism. More than grade 1/3 valvular regurgitation and/or signifant valve stenosis. Severe LV dysfunction. Planned cardiovascular intervention. Renal artery stenosis >50% of the arterial lumen, or renal artery lumen< 3 mm

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
-Main procedural study endpoint will be: Induction of ventricular arrhythmias in response to renal nerve stimulation prior to renal denervation and absence of renal nerves stimulation induced ventricular arrhythmias after renal denervation.<br /><br>-Main clinical study endpoint will be: development of ventricular arrhythmia during exercise stress testing performed 6 months after randomization.<br><br>

Secondary Outcome Measures