Renal denerVatiOn under anatomicaL and elecTrical guidance (VOLT)
- Conditions
- high blood pressurehypertension10057166
- Registration Number
- NL-OMON46881
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Patients with evidence of hypertension, treated with at least three antihypertensive drug, of which one a diuretic
Exclusion Criteria
age > 65 y
ambulantory blood pressure > 180/110 mmHg in the absence of antihypertensive medication
renal clearance < 60 ml/min (MDRD)
secundaire hypertensie
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To study blood pressure changes in response to electrical stimulation pre- and<br /><br>post-ablation in order to evaluate effective denervation.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To study the effect of renal denervation on office- and ambulatory blood<br /><br>pressure.<br /><br><br /><br>To study the effect of renal denervation on renal blood flow as expressed by<br /><br>renal flow reserve and resistance index.<br /><br><br /><br>To study the effect of renal denervation on the efferent sympathetic nervous<br /><br>system activity as expressed by catecholamine levels and natriuresis.<br /><br><br /><br>To study the effect of RDN on central sympathetic nervous activity as expressed<br /><br>by heart rate variability and peripheral arterial tonometry.</p><br>