Renal artery nerve interruption guided by location and electrical stimulatio
- Conditions
- Essential hypertension
- Registration Number
- NL-OMON23038
- Lead Sponsor
- VU medical center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Essential hypertension
- Three antihypertensive drugs, of which one a diuretic
Exclusion Criteria
- Age > 65 y
- Ambulantory blood pressure > 180/110 mmHg in the absence of antihypertensive medication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - to study blood pressure changes in response to electrical stimulation pre- and post-ablation
- Secondary Outcome Measures
Name Time Method - to study the effect of renal denervation on renal blood flow as expressed by renal flow reserve and resistance index. <br>- to study the effect of renal denervation on office- and ambulatory blood pressure. <br /><br>- to study the effect of renal denervation on the efferent sympathetic nervous system activity as expressed by catecholamine levels and natriuresis. <br /><br>- to study the effect of RDN on central sympathetic nervous activity as expressed by heart rate variability and peripheral arterial tonometry. <br>