The Effect of Embryo Culture Under a Continuous CO2 Setting Versus a Sequential CO2 Setting

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Other: Continuous CO2 Level

• Registration Number: NCT04693806
• Lead Sponsor: Reproductive Medicine Associates of New Jersey

Brief Summary

The purpose of this study is to determine if embryo culture under a single CO2 setting improves blastocyst formation rate.

Detailed Description

Following enrollment, patients will undergo ovarian stimulation and oocyte retrieval per routine as previously consented to at the clinic. IVF stimulation protocol will be at the discretion of the patient's individual provider, per routine. Intracytoplasmic Sperm Injection (ICSI) will be performed and embryos will be cultured to the blastocyst stage per routine. There are no changes to the embryology care itself, the only difference within the study is the CO2 level within the incubator pending the patient's randomization.

Study Timeline

• Study Start: 2020-12-03
• Study First Submitted: 2020-12-30
• Study First Submitted QC: 2020-12-31
• Study First Posted: 2021-01-05
• Primary Completion: 2021-01-11
• Study Completion: 2022-04-30
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-02
• Last Update Posted: 2023-05-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 102

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Continuous CO2 Level	Continuous CO2 Level	embryos will remain in a single incubator set at a continuousCO2 level

Primary Outcome Measures

Name	Time	Method
blastulation rate	approximately one week	the number of zygotes that reach the blastocyst stage

Trial Locations

Locations (1)

Reproductive Medicine Associates of New Jersey; 🇺🇸 Basking Ridge, New Jersey, United States