A Randomized Controlled Trial Evaluation the Effect of Low Oxygen Tension on the Pregnancy Rate After Day 3 Embryo Transfer in an Egg Donation Programme.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 380
- 试验地点
- 2
- 主要终点
- Clinical pregnancy rates per cycle
研究概览
简要总结
This study will determine whether the use of low oxygen tension during "in vitro" embryo culture may increase the pregnancy rates in women undergoing egg donation.
详细描述
As far as oxygen (O2) tension is concerned, both oocytes and embryos from different mammalian species included the human are normally surrounded by values which are much less than half of atmospheric O2, ranging from high (8.7% O2) in the rabbit oviduct, rabbit and hamster uterus, to as low as 11 mm Hg (1.5% O2) in the monkey uterus. Even in the preovulatory follicle, oocytes are bathed within follicular fluids containing oxygen that range from > 1 to 5.5 % The aim of this study was to evaluate the impact the effect of low oxygen tension after day-3 embryo transfer in our egg donation programme on pregnancy and implantation rates.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women aged 25-45 years of age;
- •In good mental and physical health;
- •First or second of egg-recipient treatment;
- •Embryo transfer on Day
- •One to three embryos will be transferred.
- •BMI between 18-25 kg/m2.
排除标准
- •Uterine pathology or hydrosalpinx
- •Recurrent miscarriage
- •No chronic illnesses
结局指标
主要结局
Clinical pregnancy rates per cycle
时间窗: one month
次要结局
未报告次要终点
研究者
Maria Jose Delossantos
Dr. Maria Jose Delossantos
Instituto Valenciano de Infertilidad, IVI VALENCIA