Treatment Optimisation for blood Pressure with Single-Pill combinations in India - TOPSPI

Imperial College0 个研究点目标入组 1,981 人开始时间: 待定最近更新: 2024年7月22日

试验速览

暂无简介。

•1.Age30-79 years AND
•2.Sitting clinic values (mean of the last 2 of 3 readings) of SBP = 140mmHg and <160mmHg on one antihypertensive agent OR
•3.Sitting clinic values (mean of the last 2 of 3 readings) of SBP = 150mmHg and < 180mmHg on no antihypertensive treatment

•1. Congestive heart failure (clinically defined).
•2. Patients with a history of intolerance to any of the study medications for example angioedema or dry cough with ACE--inhibitors.
•3. Serum creatinine levels greater than 132.6µmol/l(1.5mg/dl).
•4. History of coronary heart disease (i.e. chronic stable angina, myocardial infarction or acute coronary syndrome).
•5. History of a stroke or other cerebrovascular accident (i.e. transient ischaemic attack or reversible ischaemic neurological deficit).
•6. Severe hepatic impairment.
•7. Treatment with agents causing torsades de pointes.
•8.Lactation.
•9. Contraindications to any of the investigational medicinal products as per the SmPc of drugs studied.
•10. Known or suspected secondary hypertension.
•11. Any other concomitant illness, physical or mental impairment that could interfere with the effective conduct of the study.
•12. Pregnancy or those of child-bearing age who are not taking reliable contraception.
•13. History of Gout.
•14. Serum potassium <3.5mmol/L at screening.

发起方

Imperial College