NCT00079469已完成不适用
Contingency Management to Enhance Smoking Cessation for Cancer Survivors: A Proof of Concept Trial
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 1
研究概览
简要总结
RATIONALE: Contingency management is a behavioral treatment approach that provides immediate rewards for positive change in behavior such as quitting smoking. In this protocol, contingency management will be in the form of a cash reward. A smoking cessation (stop-smoking) program that combines contingency management with bupropion and counseling may be effective in helping cancer survivors stop smoking.
PURPOSE: Randomized clinical trial to compare the effectiveness of bupropion and counseling with or without contingency management in helping cancer survivors stop smoking.
详细描述
OBJECTIVES:
Primary
- Compare the feasibility of a multi-component smoking cessation intervention comprising bupropion and counseling with or without contingency management (cash reward) for cancer survivors who continue to smoke.
- Compare 7-day point-prevalence abstinence rates in patients treated with these smoking cessation interventions.
Secondary
- Determine the characteristics of these patients that predict success at quitting smoking.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Prevention
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Diagnosis of cancer at least 6 months before study entry
- •No carcinoma in situ of the cervix, basal cell or squamous cell skin cancer, or CNS tumor
- •Smoking history of at least 2 years
- •Smoked cigarettes daily for the past 30 days
- •Completed prior cancer treatment at least 6 months, but no more than 5 years before study entry
- •Concurrent tamoxifen allowed
- •PATIENT CHARACTERISTICS:
- •18 and over
- •Performance status
- •Not specified
- •Life expectancy
- •Not specified
- •Hematopoietic
- •Platelet count ≥ 100,000 - 450,000/mm^3
- •WBC ≥ 3,000/mm^3
- •AST and ALT ≤ 2 times upper limit of normal
- •Bilirubin ≤ 2.0 mg/dL
- •Creatinine < 2.0 mg/dL
- •Cardiovascular
- •No unstable cardiovascular disease, including any of the following:
- •High-grade atrioventricular block
- •Neurocardiogenic syncope
- •Unstable angina
- •Uncompensated congestive heart failure
- •Poorly controlled hypertension
- •Not pregnant or nursing
- •Negative pregnancy test
- •Able to undergo peripheral blood draw
- •No port-a-cath or Hickman catheters
- •Planning to reside in the Washington D.C. metro area for at least 1 year after study entry
- •Willing to undergo urine testing for cotinine levels and breath testing for carbon monoxide monitoring
- •No significant physical or psychological disability that would preclude study participation
- •No known allergy to bupropion
- •Baseline urine drug screen negative
- •Prescribed pain medication allowed
- •None of the following predisposing factors that may increase the risk of seizures with bupropion use:
- •History of seizures
- •Alcohol use > 4 oz/day
- •History of closed head injury
- •History of an eating disorder
- •CNS infection
- •No poorly controlled diabetes
- •PRIOR CONCURRENT THERAPY:
- •Biologic therapy
- •Not specified
- •Chemotherapy
- •Not specified
- •Endocrine therapy
- •See Disease Characteristics
- 另有 11 项未显示
排除标准
- 未提供
研究者
研究点 (1)
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