Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison

University of British Columbia1 个研究点分布在 1 个国家目标入组 48 人开始时间: 2025年7月1日最近更新: 2024年12月27日

适应症

干预措施

试验速览

阶段: 不适用
状态: 尚未招募
发起方: University of British Columbia
入组人数: 48
试验地点: 1
主要终点: Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on inflammatory cells in the lungs.

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.

详细描述

Healthy adult participants (total 48; 24 of each biological sex assigned at birth) will breathe filtered air (control), wood smoke (WS), diesel exhaust (DE), and DE plus WS (DEWS) each for 2 hours, with 4 weeks between each exposure (washout). Before and after each exposure, participants will answer questions, perform breathing tests, and give blood samples. At 24 hours after each exposure, participants will undergo a bronchoscopy to collect samples from their lungs.

The study will look at what (if any) are the differences between breathing in fresh air (filtered air - FA) or polluted air containing either wood smoke (WS), diesel exhaust (DE) or diesel exhaust plus wood smoke (DEWS). The research team will use wood smoke generated from pine wood, since it is one of the most common types of wood found in Western Canadian forests where forest fires occur.

The investigators will evaluate multiple endpoints as detailed in the Outcome Measures section. For each applicable endpoint, the investigators will evaluate stratified analyses and effect modification by biological sex, participant age, gene score, and microbiomes.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Basic Science
盲法: Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围: 19 Years 至 40 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Age 19-40
•Healthy, with no history of respiratory disease
•Lifetime non-smoker and non-vaper.

排除标准

•Pregnant, planning to become pregnant, or breastfeeding during the study period (confirmed through pregnancy tests at each visit if applicable)
•Frequent WS or DE exposures (e.g. home fireplace used for heating/cooking, or employment in transportation, mining, or as a firefighter).

研究组 & 干预措施

Filtered Air (FA)

Placebo Comparator

Participants will be exposed to 2 hours of high-efficiency particulate air (HEPA) filtered air (FA).

干预措施: Filtered Air (FA) (Other)

Wood Smoke (WS)

Active Comparator

Participants will be exposed to 2 hours of controlled wood smoke (WS) standardized to 300ug/m^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

干预措施: Wood Smoke (WS) (Other)

Diesel Exhaust (DE)

Active Comparator

Participants will be exposed to 2 hours of controlled diesel exhaust (DE) as a model of traffic-related air pollution (TRAP) standardized to 300ug/m^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

干预措施: Diesel Exhaust (DE) (Other)

Diesel Exhaust and Wood Smoke (DEWS)

Active Comparator

Participants will be exposed to 2 hours of combined controlled diesel exhaust (DE) and wood smoke (DEWS) standardized to 300ug/m^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

干预措施: Diesel Exhaust and Wood Smoke (DEWS) (Other)

结局指标

主要结局

Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on inflammatory cells in the lungs.

时间窗: Comparison of the different arms (over the span of ~5 months).

Differentially count lung cells.

Within-individual change in lung transcriptomic biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.