The effect of a preoperative lifestyle intervention in patients with acquired risk factors on perioperative glucose control and hemodynamics.
Recruiting
- Conditions
- Study subjects are identified with aquired risk factors (obesity, hypertension, dyslipidemia and physical inactivity) during health risk assessment at the Preoperative Assessment Outpatient Clinic (PAOC) and screened for impaired glucose tolerance (IGT).
- Registration Number
- NL-OMON24344
- Lead Sponsor
- VU University Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
At least two out of following risk factors:
1. Obesity (BMI >30 kg/m2);
Exclusion Criteria
1. Prior diagnosis of diabetes mellitus;
2. Anti-hypertensive therapy;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in muscular GLUT-4 expression, intracellular Akt phosphorylation and glucose tolerance after a defined increase in physical activity in the 6 weeks before surgery.
- Secondary Outcome Measures
Name Time Method 1. Changes in physical activity during lifestyle intervention (WHO guideline, daily steps taken);<br /><br>2. Influence of increased physical activity on perioperative glucose control (measured as longitudinal plasma glucose levels during surgery);<br /><br>3. Influence of increased physical activity on perioperative hemodynamics (changes in heart rate and blood pressure during surgery);<br /><br>4. Other changes in muscle cell that can possibly quantify increased physical activity (glycogen accumulation and fatty acid metabolism).