The effect of a preoperative lifestyle intervention in patients with acquired risk factors on perioperative glucose control and hemodynamics

Completed

Conditions: Impaired glucose tolerace
metabolic syndrome
10018424
10043413

Registration Number: NL-OMON36362

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

The patient has at least two of the following lifestyle risk factors:
- Overweight (BMI >25 kg/m2)
- Hypertension (systolic blood pressure>140 mmHg and/or diastolic blood pressure>90 mmHg)
- Physical inactivity (< 30 min/day of moderate activity, like walking or cycling)
In combination with: Newly identified impaired glucose tolerance;General inclusion criteria
* Newly identified impaired glucose tolerance (IGT)
* Age between 40 and 75 years
* Undergoing elective surgery not sooner than 8 weeks after the PAOC visit
* Non-cardivascular surgery with a minimal duration of 60 minutes
* ASA class I-III
* Able to walk independent of assistance
* Signed informed consent

Exclusion Criteria

- Prior diagnosis of diabetes mellitus
- Not fit enough to participate in this study
- ASA class IV

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in muscular GLUT-4 expression after increased physical activity</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Changes in physical activity during lifestyle intervention (daily steps taken)<br /><br>Influence of increased physical activity on perioperative glucose control<br /><br>(measured as longitudinal plasma glucose levels during surgery)<br /><br>*Influence of increased physical activity on perioperative hemodynamics.<br /><br>Influence of increased physical activity on heart rate variability </p><br>