ISRCTN29176549进行中（未招募）Unknown
Comparing the effects of acute versus chronic, flavanol-rich cocoa intake on cerebral haemodynamics, metabolism, and cognitive function in healthy young (18 to 40 year-old) and older (65 + year-old) adults
适应症
试验速览
- 阶段
- Unknown
- 状态
- 进行中（未招募）
- 入组人数
- 100
- 主要终点
- Prefrontal cortical concentrations of oxygenated and deoxygenated haemoglobin will be measured using broadband near-infrared spectroscopy (bNIRS) during rest and physiological stress (i.e., hypoxia simulated with 11% oxygen delivery) at the following time points: i) on day 1, before (0 hours) and 2 hours after supplementation with either low- or high-flavanol cocoa (acute effect); ii) on day 28 and day 56, before (0 hours) cocoa supplementation (chronic effect); and iii) on day 56, 2 hours after cocoa supplementation (acute within chronic effect).
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Healthy male or female
- •Aged between 18 to 40 years old OR above 65 years old
排除标准
- •Consumption of more than 21 units of alcohol per week
- •A history of cardiovascular, respiratory, metabolic, liver, inflammatory, or neurological diseases, including but not limited to hypertension (blood pressure >140/90 mmHg), diabetes mellitus, asthma, elevated cholesterol, anemia, immune conditions, and smoking
- •Use of prescribed or over-the-counter medications (except for oral contraception)
- •Allergies or intolerances to any ingredients in the dietary supplement
- •Currently following a weight-reducing dietary regimen
- •Use of any dietary supplements, including fatty acids and vitamins
- •Long-term medication use or use of antibiotics in the past 3 months
- •Current infection (e.g., cold)
- •Pregnancy or plans to become pregnant (for females of reproductive age)
结局指标
主要结局
Prefrontal cortical concentrations of oxygenated and deoxygenated haemoglobin will be measured using broadband near-infrared spectroscopy (bNIRS) during rest and physiological stress (i.e., hypoxia simulated with 11% oxygen delivery) at the following time points: i) on day 1, before (0 hours) and 2 hours after supplementation with either low- or high-flavanol cocoa (acute effect); ii) on day 28 and day 56, before (0 hours) cocoa supplementation (chronic effect); and iii) on day 56, 2 hours after cocoa supplementation (acute within chronic effect).
次要结局
未报告次要终点
研究者
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