Acute Effects of Three Doses of Spirulina in Glucose Beverages on Postprandial Glycemic Responses, Arterial Blood Pressure, and Subjective Appetite Responses: A Randomized Clinical Trial
Overview
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- Capillary blood glucose responses
Overview
Brief Summary
This study investigated the effects of three doses of spirulina in glucose beverages on postprandial glycemic responses, arterial blood pressure, and subjective satiety.
Detailed Description
This study aimed to determine the effects of three different doses (4, 6 and 8 g) of spirulina in glucose beverages on postprandial glycemic responses, blood pressure, and subjective appetite responses in healthy young adults.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Other
- Masking
- Double (Participant, Investigator)
Masking Description
Double blind
Eligibility Criteria
- Ages
- 18 Years to 55 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •non-smokers
- •men and women
- •body mass index between 18 and 24.9 kg/m2
- •normal blood pressure (systolic blood pressure \<120 mmHg and diastolic blood pressure \<80 mmHg)
- •normal fasting blood glucose concentrations (\<100 mg/dL)
Exclusion Criteria
- •Medical conditions (e.g., cardiovascular diseases, diabetes mellitus, kidney or liver conditions, severe clinical depression, gastrointestinal disorders)
- •Under medications known to affect glycemia (glucocorticoids, metformin, thiazide diuretics)
- •Allergy to spirulina
- •Pregnancy
- •Lactation
- •Competitive sports
- •Alcohol abuse
- •Drug dependency
Outcomes
Primary Outcomes
Capillary blood glucose responses
Time Frame: 2 hours
Clinically useful change in blood glucose, defined as the restoration of glucose within normal limits during 2hr glucose tolerance test
Blood pressure
Time Frame: 2 hours
Useful change in systolic and diastolic blood pressure before and 2hr after consumption of the three doses of spirulina in beverages
Secondary Outcomes
- Subjective appetite ratings(2 hours)
Investigators
Aimilia Papakonstantinou
Assistant Professor in Nutrition and Metabolism
Agricultural University of Athens