Acute Effects of Spirulina on Postprandial Glycemic Responses and Arterial Blood Pressure

Not Applicable

Completed

• Conditions: Appetitive Behavior; Blood Pressure; Potential Abnormality of Glucose Tolerance

• Registration Number: NCT05484336
• Lead Sponsor: Agricultural University of Athens

Brief Summary

This study investigated the effects of three doses of spirulina in glucose beverages on postprandial glycemic responses, arterial blood pressure, and subjective satiety.

Detailed Description

This study aimed to determine the effects of three different doses (4, 6 and 8 g) of spirulina in glucose beverages on postprandial glycemic responses, blood pressure, and subjective appetite responses in healthy young adults.

Study Timeline

• Study Start: 2022-06-07
• Status Verified: 2022-07
• Primary Completion: 2022-07-15
• Study Completion: 2022-07-26
• Study First Submitted: 2022-07-30
• Study First Submitted QC: 2022-07-30
• Last Update Submitted: 2022-07-30
• Study First Posted: 2022-08-02
• Last Update Posted: 2022-08-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• healthy
• non-smokers
• men and women
• body mass index between 18 and 24.9 kg/m2
• normal blood pressure (systolic blood pressure <120 mmHg and diastolic blood pressure <80 mmHg)
• normal fasting blood glucose concentrations (<100 mg/dL)

Exclusion Criteria

• Medical conditions (e.g., cardiovascular diseases, diabetes mellitus, kidney or liver conditions, severe clinical depression, gastrointestinal disorders)
• Under medications known to affect glycemia (glucocorticoids, metformin, thiazide diuretics)
• Allergy to spirulina
• Pregnancy
• Lactation
• Competitive sports
• Alcohol abuse
• Drug dependency

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Capillary blood glucose responses	2 hours	Clinically useful change in blood glucose, defined as the restoration of glucose within normal limits during 2hr glucose tolerance test
Blood pressure	2 hours	Useful change in systolic and diastolic blood pressure before and 2hr after consumption of the three doses of spirulina in beverages

Secondary Outcome Measures

Name	Time	Method
Subjective appetite ratings	2 hours	Useful change in subjective appetite using visual analogue scales with a score 0 to 10 (given in form of booklet, one scale per page) at baseline, 15, 30, 45, 60, 90 and 120. The minimum or maximum score will be evaluated if it is better or worse depending on the appetite variable e.g. hunger, satiety, desire to eat etc.

Trial Locations

Locations (1)

Agricultural University of Athens; 🇬🇷 Athens, Attica, Greece