Acute Effect of Crocus Sativus on Postprandial Glycemia

Not Applicable

Completed

• Conditions: Potential Abnormality of Glucose Tolerance; Blood Pressure; Appetitive Behavior

• Registration Number: NCT05484362
• Lead Sponsor: Agricultural University of Athens

Brief Summary

This study investigated the effects of two different doses of Crocus Sativus in glucose beverages on glycemic responses.

Detailed Description

This study examined the short-term effects of two different doses (15 mg and 30 mg) of Crocus Sativus in glucose beverages on postprandial glycemic responses in healthy young adults.

Study Timeline

• Study Start: 2022-06-06
• Status Verified: 2022-07
• Primary Completion: 2022-07-10
• Study Completion: 2022-07-26
• Study First Submitted: 2022-07-30
• Study First Submitted QC: 2022-07-30
• Last Update Submitted: 2022-07-30
• Study First Posted: 2022-08-02
• Last Update Posted: 2022-08-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Healthy
• Non-smoking
• Non-diabetic men and women
• Body Mass Index (BMI) between 18.5 and 24.9 kg/m2
• Normal blood pressure

Exclusion Criteria

• Severe chronic disease (e.g., coronary heart disease, diabetes mellitus, kidney or liver conditions, endocrine conditions)
• Gastrointestinal disorders
• Pregnancy
• Lactation
• Competitive sports
• Alcohol abuse
• Drug dependency
• Allergy in Crocus Sativus

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Capillary blood glucose responses	2 hours	Clinically useful change in blood glucose, defined as the restoration of glucose within normal limits during the 2-hour oral glucose tolerance test

Secondary Outcome Measures

Name	Time	Method
Subjective appetite ratings	2 hours	Useful change in subjective appetite using visual analogue scales with a score from 0 to 10 (given in the form of booklet, one scale per page) at baseline, 15, 30, 45, 60, 90 and 120 min. The minimum or maximum score will be evaluated if it is better or worse depending on the appetite variable e.g., hunger, satiety, desire to eat etc.
Blood pressure	2 hours	Useful change in systolic and diastolic blood pressure before and 2-hour after consumption of the three beverages

Trial Locations

Locations (1)

Agricultural University of Athens; 🇬🇷 Athens, Attica, Greece