Sarcopenia in Axial and Peripheral Spondyloarthropathies

Not Applicable

Completed

• Conditions: Sarcopenia; Spondylarthropathy
• Interventions: Other: Dynamometry exam; Other: Walking test; Radiation: DXA measurement; Other: SARQOL questionnaire; Behavioral: Life habits Questionnaire

• Registration Number: NCT03319264
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Spondylarthropathies (SpA) are among the most common chronic inflammatory rheumatisms in adults, responsible for a muscular loss or sarcopenia which can be very disabling, not much documented in the literature, and not yet studied in France. In addition, sarcopenia is associated with decreased physical activity and increased risk of falls and fractures. A better characterization of the determinants of this muscular loss will allow to better detect and take care of it.

The aim is to conduct the first French study on the prevalence and severity of sarcopenia in patients with spondyloarthropathies and to study the variables that may be associated with it. Finally, we propose to evaluate obesity related to sarcopenia in these patients and compare them to cases matched for age and sex (from OFELY / STRAMBO cohorts, Lyon, FRANCE).

This is a prospective interventional and monocentric study with minimal risks and constraints: patients will be included for one day for an evaluation of their sarcopenia by measuring their muscle strength, physical performance and body composition and recording of their socio-demographic and disease characteristics.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-10-18
• Study First Submitted QC: 2017-10-23
• Study First Posted: 2017-10-24
• Study Start: 2017-11-02
• Primary Completion: 2018-07-04
• Study Completion: 2018-07-04
• Status Verified: 2018-09
• Last Update Submitted: 2018-09-06
• Last Update Posted: 2018-09-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

• Men and women, 18 to 80 years old
• Hospitalized or attending the rheumatology department for spondyloarthopathy.

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Exclusion Criteria

• no signed consent
• Immobilization for a period of more than 15 days during the last 3 months
• pregnant or breastfeeding woman
• Not affiliated to the national healthcare insurance
• difficulty in understanding French
• psychiatric disorder

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients with SpA	Dynamometry exam	Patients included in this single group study will have 3 interventions to assess the severity of muscle loss : * dynamometry exam * walking test * Dual-energy X-ray Absorptiometry (DXA) measurement Quality of life will be assessed with Sarcopenia \& Quality of Life (SARQOL) questionnaire. Patients will also fill a Life habits Questionnaire.
Patients with SpA	Walking test	Patients included in this single group study will have 3 interventions to assess the severity of muscle loss : * dynamometry exam * walking test * Dual-energy X-ray Absorptiometry (DXA) measurement Quality of life will be assessed with Sarcopenia \& Quality of Life (SARQOL) questionnaire. Patients will also fill a Life habits Questionnaire.
Patients with SpA	SARQOL questionnaire	Patients included in this single group study will have 3 interventions to assess the severity of muscle loss : * dynamometry exam * walking test * Dual-energy X-ray Absorptiometry (DXA) measurement Quality of life will be assessed with Sarcopenia \& Quality of Life (SARQOL) questionnaire. Patients will also fill a Life habits Questionnaire.
Patients with SpA	DXA measurement	Patients included in this single group study will have 3 interventions to assess the severity of muscle loss : * dynamometry exam * walking test * Dual-energy X-ray Absorptiometry (DXA) measurement Quality of life will be assessed with Sarcopenia \& Quality of Life (SARQOL) questionnaire. Patients will also fill a Life habits Questionnaire.
Patients with SpA	Life habits Questionnaire	Patients included in this single group study will have 3 interventions to assess the severity of muscle loss : * dynamometry exam * walking test * Dual-energy X-ray Absorptiometry (DXA) measurement Quality of life will be assessed with Sarcopenia \& Quality of Life (SARQOL) questionnaire. Patients will also fill a Life habits Questionnaire.

Primary Outcome Measures

Name	Time	Method
Walking speed	At day 1	Walking speed is a physical performance outcome, that is the second outcome to evaluate sarcopenia
Muscular mass	Up to 4 month after inclusion	Muscular mass is the third outcome to evaluate sarcopenia and will be assessed using DXA
Muscular strength	At day 1	Muscular strength is the first outcome to evaluate sarcopenia

Secondary Outcome Measures

Name	Time	Method
Score at the SARQOL questionnaire	At day 1	Quality of life will be assessed thanks to the SARQOL questionnaire (score between 0 and 100)
Tobacco consumption	At day 1
Alcohol consumption	At day 1
Physical activity rate in work	At day 1	Physical activity rate in work can be light, medium, high or not applicable if the patient does not work ; it is the second outcome to evaluate patient's physical global activity.
Average walking time in a week	At day 1	Average walking time in a week is the third outcome to evaluate patient's physical global activity.
Time of sport practice per month	At day 1	Number of hours of sport practice per month is the first outcome to evaluate patient's global physical activity.

Trial Locations

Locations (1)

Service de Rhumatologie - Hôpital Edouard Herriot; 🇫🇷 Lyon, France