An Observational Study of the Cardiovascular Response to Infiltration of Local Anaesthetic Into the Nasal Septum in Patients Undergoing Trans-sphenoidal Resection of a Pituitary Lesion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 主要终点
- Change in blood pressure after administration of local anaesthesia
研究概览
简要总结
The purpose of this study is to determine the effects on the heart of injecting local anaesthetic into the nose prior to surgery on the pituitary gland?
详细描述
People sometimes require surgery on their pituitary gland. This is a gland at the base of your brain which secretes hormones. At the Royal Hallamshire Hospital the investigators are currently conducting a study into the effects of local anaesthetic (a medicine which causes numbness) injection on patients undergoing this particular type of operation.
After patients are anaesthetised (asleep) but before surgery starts the surgeon injecst a local anaesthetic solution into the nose. This is routine practice and is done to provide pain relief afterwards and also to decrease the amount of bleeding during the operation to ensure that the surgeon has a good view.
The investigators have known for a long time that local anaesthetic affects the heart rate and blood pressure, however the investigators would like to describe exactly how, in much more detail.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 17 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any adult patient undergoing trans-sphenoidal pituitary surgery.
排除标准
- •Under 16 years of age, pregnancy, uncontrolled hypertension, allergy to any local anaesthetic, patient refusal or revision pituitary surgery.
研究组 & 干预措施
Pituitary Surgery
Patients having pituitary gland surgery
Inclusion criteria - Any adult patient undergoing trans-sphenoidal pituitary surgery.
Exclusion criteria - Under 16 years of age, pregnancy, uncontrolled hypertension, allergy to any local anaesthetic, patient refusal or revision pituitary surgery
干预措施: Pituitary surgery (Procedure)
Pituitary Surgery
Patients having pituitary gland surgery
Inclusion criteria - Any adult patient undergoing trans-sphenoidal pituitary surgery.
Exclusion criteria - Under 16 years of age, pregnancy, uncontrolled hypertension, allergy to any local anaesthetic, patient refusal or revision pituitary surgery
干预措施: local anaesthetic injection (Drug)
结局指标
主要结局
Change in blood pressure after administration of local anaesthesia
时间窗: 5 minutes
Changes in mean arterial pressure from baseline after infiltration of local anaesthetic.
次要结局
- Change in heart rate after administration of local anaesthesia(5 minutes)
- Change in cardiac output after administration of local anaesthesia(5 minutes)
- Change in systemic vascular resistance after administration of local anaesthesia(5 minutes)