Effect Of Rural-Urban Settings And Parasitic Infections On The Immune System And Vaccination Responses: A Study In Kilimanjaro And Arusha Regions In Tanzania
- Conditions
- Studying immune system variation and variation in vaccine response using yellow fever vaccine.
- Registration Number
- PACTR202405738173023
- Lead Sponsor
- Kilimanjaro Christian Medical Centre KCMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 200
1.People who are permanent residents of the selected areas and expected to stay during the whole duration of the study
2.Aged 18-35 years
3.Accepted written consent
1.Clinically significant history of diseases like HIV, TB, Cancer, Cardiovascular diseases, gastrointestinal disease, liver disease, renal disease, an endocrine disorder, or neurological illness.
2.History of recurrent infections and being admitted 2 or more times a year at hospital and receiving antibiotics as it will be shown in discharge summary.
3.History of long-term use of corticosteroids for any reasons, i.e. concurrent oral or systemic steroids medication or the concurrent use of other immunosuppressive agents within 2 to 3 months before enrolment.
4.Hospital admission in the past 3 months
5.Any history of being the recipient of vaccines that will be used during the study
6.Positive HIV serology
7.Haemoglobin levels less than 8.5 g/dl
8.A positive pregnancy test at the start or during the study
9.History of nose bleeding
10.Female currently lactating
11.Transfusion of blood products within three months before the study
12.Received immunoglobulins within three months before the study
13.Low blood pressure =90/60 mm Hg
14.High blood glucose >7.1 mmol l-1 fastings or >11.1 mmol l-1 random RBG
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method