Effect of rTMS on motor and nonmotor symptoms of progressive surpanuclear plasy : Randomised controlled study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- to study efficacy in motor and nonmotor symptoms after cerebellar rTMS in progressive supranuclear palsy compared to sham procedure
研究概览
简要总结
this is a randomized placebo controlled trial to assess the efficacy of repetitive transcranial magnetic stimuli in motor and non motor symptoms of progressive supranuclear palsy. this trial is conducted to assess various parameters and improvement in gait after the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Double
入排标准
- 年龄范围
- 40.00 Year(s) 至 85.00 Year(s)（—）
- 性别
- All
入选标准
- •probable or possible PSP defined by MDS criteria ability to stand unassisted for 30 seconds and ability to walk independently with walker MMSE 18 or more on stable treatment of anticholinergic, dopaminergic , serotonergic sedative or NMDA receptor antagonist.
排除标准
- •history of cerebellar ataxia, subdural hematoma, space occupying lesion, hydrocephalus prior vestibular disease sensory deficit in feet epilepsy and psychotic disorder active intake of antiseizure medication pregnancy presence of electrically, magnetically active implants or metal exposures that preclude use of rTMS.
结局指标
主要结局
to study efficacy in motor and nonmotor symptoms after cerebellar rTMS in progressive supranuclear palsy compared to sham procedure
时间窗: patient will be assessed at the time of enrollment, at 1 month and at 6 months
with parameters like
时间窗: patient will be assessed at the time of enrollment, at 1 month and at 6 months
PSP rating scale
时间窗: patient will be assessed at the time of enrollment, at 1 month and at 6 months
MDS non motor rating scale
时间窗: patient will be assessed at the time of enrollment, at 1 month and at 6 months
UPDRS part III
时间窗: patient will be assessed at the time of enrollment, at 1 month and at 6 months
PSP CDS
时间窗: patient will be assessed at the time of enrollment, at 1 month and at 6 months
MOCA
时间窗: patient will be assessed at the time of enrollment, at 1 month and at 6 months
FAB
时间窗: patient will be assessed at the time of enrollment, at 1 month and at 6 months
次要结局
- to look for non motor and behavioral changes in patients with PSP(patient will be assessed at the time of enrollment, at 1 month and at 6 months)
研究者
Dr Deepika Joshi
IMS, BHU, varanasi