The efficacy of progestin primed ovarian stimulation (PPOS) during controlled ovarian stimulation(COS) for patients with endometriosis
- Conditions
- infertility
- Registration Number
- JPRN-UMIN000031111
- Lead Sponsor
- Kamiya Ladies Clinic
- Brief Summary
During this study, no premature LH surge was detected. A smaller number of oocytes were retrieved in the dienogest(DNG) group than in the dydrogesterone(DYG) group (6.18 vs. 9.85); however, the rate of mature oocytes was significantly higher in the DNG group than in the DYG group (89.1% vs. 78.9%). The fertilization rate was comparable between two groups. Therefore, patients taking DNG for PPOS can continue endometriosis treatment and obtain good-quality embryos during COH.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 150
Not provided
1) Patients who documented cycles with no oocyte retrieved, any contraindications to ovarian stimulation treatment and 2) patients who has contraindication to DNG, GnRHa, EP, FSH, HMG, HCG 3) Patients who is judged to be inappropriate for this study by the doctor
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The clinical pregnancy rate
- Secondary Outcome Measures
Name Time Method 1) total amount of FSH/HMG 2) number of growing follicle (<15mm) and mature follicle (<18mm), number of oocyte retrieved 3)the incidence of premature LH surge 4) fertilization rate, implantation rate 5) serum concentration of estradiol and progesterone (on the trigger day) 6) the incidence of OHSS 7) the viable embryo rate 8) ongoing pregnancy rate, early miscarriage rate, multiple pregnancy rate