Influence of severe heart failure to function andmolecular biological parameters of catabolism in the human Diaphragm and peripheral skeletal muscle - LIPAMUS-HF

Herzzentrum Leipzig GmbHUniversitätsklinik für Kardiologie0 个研究点目标入组 44 人开始时间: 2016年1月5日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•inclusion criteria Group A:
•- age 40 – 70 years
•- Restricted left ventricular pump function LVEF> 35% on the basis of ischemic cardiomyopathy (ICM) and restricted resting cardiac output (CI> 2.4 L / min / m²)
•- or restricted maximal oxygen uptake (VO2max> 17 ml / min / m²)
•- Duration of heart failure> 1 year
•- Maximum of individual heart failure therapy
•- Heart team decision to LVAD Implantation
•inclusion criteria Group B:
•- age 40 – 70 years
•- Restricted left ventricular pump function LVEF> 35% on the basis of dilatiative cardiomyopathy (DCM) and restricted resting cardiac output (CI> 2.4 L / min / m²)
•- or restricted maximal oxygen uptake (VO2max> 17 ml / min / m²)
•- Duration of heart failure> 1 year
•- Maximum of individual heart failure therapy
•- Heart team decision to LVAD Implantation
•inclusion criteria Group C:
•- age 40 - 70 years
•- coronary heart disease with indication for elective, coronary artery bypass surgery
•- normal LV pumping function LVEF> 50%
•- stable clinical situation (no cardiac decompensation within the last 6 months)

•· Mechanical ventilation within the last 3 months
•· FEV1 <70% of the norm and / or therapy with
•a antagonists, ß-mimetics or
•inhaled corticosteroids for the treatment of a lung disease
•· Pulmonary fibrosis
•· elevated diaphragm in the ultrasound or X-ray diagnosis or known paresis of the phrenic nerve
•· renal insufficiency CKD stage 4 and 5, i.e. GFR <30ml / min / 1.73m and / or dialysis
•· Acute renal failure
•· Treatment with immunosuppressive agents
•· Hepatic insufficiency Child-Pugh B and C
•· Higher grade ventricular arrhythmias (Lown IV b)
•· Acute myocardial infarction (less than three months)
•· Decompensated Vitium cordis
•· Age <40 years and> 70 years
•· Pregnancy

发起方

Herzzentrum Leipzig GmbHUniversitätsklinik für Kardiologie