Skip to main content
Clinical Trials/DRKS00009848
DRKS00009848CompletedNot Applicable

Influence of severe heart failure to function andmolecular biological parameters of catabolism in the human Diaphragm and peripheral skeletal muscle - LIPAMUS-HF

Herzzentrum Leipzig GmbHUniversitätsklinik für Kardiologie0 sites44 target enrollmentStarted: January 5, 2016Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
44

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Observational

Eligibility Criteria

Ages
40 Years to 70 Years (—)
Sex
All

Inclusion Criteria

  • inclusion criteria Group A:
  • - age 40 – 70 years
  • - Restricted left ventricular pump function LVEF> 35% on the basis of ischemic cardiomyopathy (ICM) and restricted resting cardiac output (CI> 2.4 L / min / m²)
  • - or restricted maximal oxygen uptake (VO2max> 17 ml / min / m²)
  • - Duration of heart failure> 1 year
  • - Maximum of individual heart failure therapy
  • - Heart team decision to LVAD Implantation
  • inclusion criteria Group B:
  • - age 40 – 70 years
  • - Restricted left ventricular pump function LVEF> 35% on the basis of dilatiative cardiomyopathy (DCM) and restricted resting cardiac output (CI> 2.4 L / min / m²)
  • - or restricted maximal oxygen uptake (VO2max> 17 ml / min / m²)
  • - Duration of heart failure> 1 year
  • - Maximum of individual heart failure therapy
  • - Heart team decision to LVAD Implantation
  • inclusion criteria Group C:
  • - age 40 - 70 years
  • - coronary heart disease with indication for elective, coronary artery bypass surgery
  • - normal LV pumping function LVEF> 50%
  • - stable clinical situation (no cardiac decompensation within the last 6 months)

Exclusion Criteria

  • · Mechanical ventilation within the last 3 months
  • · FEV1 <70% of the norm and / or therapy with
  • a antagonists, ß-mimetics or
  • inhaled corticosteroids for the treatment of a lung disease
  • · Pulmonary fibrosis
  • · elevated diaphragm in the ultrasound or X-ray diagnosis or known paresis of the phrenic nerve
  • · renal insufficiency CKD stage 4 and 5, i.e. GFR <30ml / min / 1.73m and / or dialysis
  • · Acute renal failure
  • · Treatment with immunosuppressive agents
  • · Hepatic insufficiency Child-Pugh B and C
  • · Higher grade ventricular arrhythmias (Lown IV b)
  • · Acute myocardial infarction (less than three months)
  • · Decompensated Vitium cordis
  • · Age <40 years and> 70 years
  • · Pregnancy

Investigators

Sponsor
Herzzentrum Leipzig GmbHUniversitätsklinik für Kardiologie

Similar Trials