DRKS00009848CompletedNot Applicable
Influence of severe heart failure to function andmolecular biological parameters of catabolism in the human Diaphragm and peripheral skeletal muscle - LIPAMUS-HF
Herzzentrum Leipzig GmbHUniversitätsklinik für Kardiologie0 sites44 target enrollmentStarted: January 5, 2016Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 44
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 40 Years to 70 Years (—)
- Sex
- All
Inclusion Criteria
- •inclusion criteria Group A:
- •- age 40 – 70 years
- •- Restricted left ventricular pump function LVEF> 35% on the basis of ischemic cardiomyopathy (ICM) and restricted resting cardiac output (CI> 2.4 L / min / m²)
- •- or restricted maximal oxygen uptake (VO2max> 17 ml / min / m²)
- •- Duration of heart failure> 1 year
- •- Maximum of individual heart failure therapy
- •- Heart team decision to LVAD Implantation
- •inclusion criteria Group B:
- •- age 40 – 70 years
- •- Restricted left ventricular pump function LVEF> 35% on the basis of dilatiative cardiomyopathy (DCM) and restricted resting cardiac output (CI> 2.4 L / min / m²)
- •- or restricted maximal oxygen uptake (VO2max> 17 ml / min / m²)
- •- Duration of heart failure> 1 year
- •- Maximum of individual heart failure therapy
- •- Heart team decision to LVAD Implantation
- •inclusion criteria Group C:
- •- age 40 - 70 years
- •- coronary heart disease with indication for elective, coronary artery bypass surgery
- •- normal LV pumping function LVEF> 50%
- •- stable clinical situation (no cardiac decompensation within the last 6 months)
Exclusion Criteria
- •· Mechanical ventilation within the last 3 months
- •· FEV1 <70% of the norm and / or therapy with
- •a antagonists, ß-mimetics or
- •inhaled corticosteroids for the treatment of a lung disease
- •· Pulmonary fibrosis
- •· elevated diaphragm in the ultrasound or X-ray diagnosis or known paresis of the phrenic nerve
- •· renal insufficiency CKD stage 4 and 5, i.e. GFR <30ml / min / 1.73m and / or dialysis
- •· Acute renal failure
- •· Treatment with immunosuppressive agents
- •· Hepatic insufficiency Child-Pugh B and C
- •· Higher grade ventricular arrhythmias (Lown IV b)
- •· Acute myocardial infarction (less than three months)
- •· Decompensated Vitium cordis
- •· Age <40 years and> 70 years
- •· Pregnancy
Investigators
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