Influence of severe heart failure to function andmolecular biological parameters of catabolism in the human Diaphragm and peripheral skeletal muscle - LIPAMUS-HF

Herzzentrum Leipzig GmbHUniversitätsklinik für Kardiologie0 sites44 target enrollmentJanuary 5, 2016

ConditionsI50.14

Overview

No summary available.

Registry

who.int

Start Date

January 5, 2016

End Date

March 31, 2018

Last Updated

last year

Study Type

Observational

Sex

All

Sponsor

Herzzentrum Leipzig GmbHUniversitätsklinik für Kardiologie

•inclusion criteria Group A:
•\- age 40 – 70 years
•\- Restricted left ventricular pump function LVEF\> 35% on the basis of ischemic cardiomyopathy (ICM) and restricted resting cardiac output (CI\> 2\.4 L / min / m²)
•\- or restricted maximal oxygen uptake (VO2max\> 17 ml / min / m²)
•\- Duration of heart failure\> 1 year
•\- Maximum of individual heart failure therapy
•\- Heart team decision to LVAD Implantation
•inclusion criteria Group B:
•\- age 40 – 70 years
•\- Restricted left ventricular pump function LVEF\> 35% on the basis of dilatiative cardiomyopathy (DCM) and restricted resting cardiac output (CI\> 2\.4 L / min / m²)

•· Mechanical ventilation within the last 3 months
•· FEV1 \<70% of the norm and / or therapy with
•a antagonists, ß\-mimetics or
•inhaled corticosteroids for the treatment of a lung disease
•· Pulmonary fibrosis
•· elevated diaphragm in the ultrasound or X\-ray diagnosis or known paresis of the phrenic nerve
•· renal insufficiency CKD stage 4 and 5, i.e. GFR \<30ml / min / 1\.73m and / or dialysis
•· Acute renal failure
•· Treatment with immunosuppressive agents
•· Hepatic insufficiency Child\-Pugh B and C