Effects of Fatty and Lean Fish Intake on Cardiovascular Risk Factors in Subjects With Coronary Heart Disease

Not Applicable

Completed

• Conditions: Blood Pressure; Arrhythmia; Inflammation
• Interventions: Other: Dietary intervention

• Registration Number: NCT00720655
• Lead Sponsor: University of Eastern Finland

Brief Summary

The aim of the study is to examine the effects of fatty fish and white (lean) fish on cardiovascular disease risk factor levels in subjects with established coronary heart disease using multiple medications. The main end points are blood pressure, serum lipids, inflammatory markers, arrhythmias and gene expression in peripheral mononuclear cells. The study design was a controlled, parallel study lasting 8 weeks with three diet groups: fatty fish, white fish and control group (lean pork, beef or chicken).

Detailed Description

Not available

Study Timeline

• Study Start: 2005-08
• Primary Completion: 2006-12
• Study First Submitted: 2008-07-21
• Study First Submitted QC: 2008-07-22
• Study First Posted: 2008-07-23
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-21
• Last Update Posted: 2014-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• myocardial infarction or unstable ischemic attack
• use of beta blockers
• normal sinus rhythm
• fasting serum triglyceride less or equal to 3.5 mmol/l
• fasting serum cholesterol less or equal to 8 mmol/l
• BMI 18.5-30 kg/m2
• fasting plasma glucose less or equal to 7 mmol/l

Exclusion Criteria

• diabetes
• use of other antiarrhythmic medications than beta blockers
• atrial fibrillation
• use of psychotropic medications
• abnormal liver, thyroid or kidney function
• inflammatory bowel disease
• excessive use of alcohol
• use of fish oil supplements or high habitual intake of fish

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control diet	Dietary intervention	-
Fatty fish	Dietary intervention	-
Lean Fish	Dietary intervention	-

Primary Outcome Measures

Name	Time	Method
gene expression in peripheral mononuclear blood cells, risk of arrhythmias, serum lipids and blood pressure	8 week

Secondary Outcome Measures

Name	Time	Method
inflammatory markers	8 week

Trial Locations

Locations (1)

University of Kuopio; 🇫🇮 Kuopio, Finland