NCT00720655已完成不适用
Effects of Fatty and Lean Fish Intake on Cardiovascular Risk Factors in Subjects With Coronary Heart Disease
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- gene expression in peripheral mononuclear blood cells, risk of arrhythmias, serum lipids and blood pressure
研究概览
简要总结
The aim of the study is to examine the effects of fatty fish and white (lean) fish on cardiovascular disease risk factor levels in subjects with established coronary heart disease using multiple medications. The main end points are blood pressure, serum lipids, inflammatory markers, arrhythmias and gene expression in peripheral mononuclear cells. The study design was a controlled, parallel study lasting 8 weeks with three diet groups: fatty fish, white fish and control group (lean pork, beef or chicken).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •myocardial infarction or unstable ischemic attack
- •use of beta blockers
- •normal sinus rhythm
- •fasting serum triglyceride less or equal to 3.5 mmol/l
- •fasting serum cholesterol less or equal to 8 mmol/l
- •BMI 18.5-30 kg/m2
- •fasting plasma glucose less or equal to 7 mmol/l
排除标准
- •use of other antiarrhythmic medications than beta blockers
- •atrial fibrillation
- •use of psychotropic medications
- •abnormal liver, thyroid or kidney function
- •inflammatory bowel disease
- •excessive use of alcohol
- •use of fish oil supplements or high habitual intake of fish
研究组 & 干预措施
Fatty fish
Experimental
干预措施: Dietary intervention (Other)
Lean Fish
Experimental
干预措施: Dietary intervention (Other)
Control diet
Placebo Comparator
干预措施: Dietary intervention (Other)
结局指标
主要结局
gene expression in peripheral mononuclear blood cells, risk of arrhythmias, serum lipids and blood pressure
时间窗: 8 week
次要结局
- inflammatory markers(8 week)
研究者
研究点 (1)
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