Assessment of platelet rich plasma injection in clinical outcome and MRI findings in patients with knee osteoarthritis

Phase 3

• Conditions: knee osteoarthritis.; Gonarthrosis [arthrosis of knee]

• Registration Number: IRCT2014020413442N6
• Lead Sponsor: Physical Medicine and Rehabilitation Department of Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

arthralgia since past 3 months; radiologic evidence of articular damage (grade 1-4 of Kellgren-Lawrence scale) based on knee OA criteria of ACR. Exclusion criteria: systemic diseases such as diabetes mellitus and collagen vascular disorders; history or presence of cancer or malignant disorders; any infection and active wound of the knee; presence of immunosuppressive, autoimmune and platelet disorders; treatment with anticoagulant and anti-platelet medications 10 days before injection; use of NSAIDs 2 days before injection; history of knee articular injections of corticosteroids 3 weeks or use of systemic corticosteroids 2 weeks before PRP injections; hemoglobin measures of less than 12 g/dl and platelet counts of less than 150,000 per micro liter; recent history of severe trauma to the knee; age less than 45 or over 75 year; history of vasovagal shock; pregnancy; breastfeeding; genu valgum/varum greater than 20 degrees; contraindication for MRI including aneurysm clips,pacemaker,metallic devices and claustrophobia.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cartilage lesion. Timepoint: before intervention & 6 months after intervention. Method of measurement: WORMS criteria.;Joint stiffness. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Function. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Knee pain. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Knee pain. Timepoint: before intervention & 6 months after intervention. Method of measurement: VAS.;Bone marrow edema. Timepoint: before intervention & 6 months after intervention. Method of measurement: WORMS criteria.;Meniscus lesion. Timepoint: before intervention & 6 months after intervention. Method of measurement: WORMS criteria.;Synovitis. Timepoint: before intervention & 6 months after intervention. Method of measurement: WORMS criteria.