DRKS00016158
Recruiting
N/A
Genetic screening of an at-risk population for Hereditary TransthyRetin-related AMyloidosis and longitudinal monitoring of TTR positive subjects - TRAMmoniTTR
Centogene AG Rostock0 sites5,000 target enrollmentMarch 12, 2019
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Centogene AG Rostock
- Enrollment
- 5000
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Informed consent is obtained from the participant
- •The participant has no diagnosis of alcoholism according to international guidelines
- •The participant has not undergone chemotherapy for any carcinoma
- •The participant is at risk for hATTR due to two or more the factors listed below:
- •\- cardiomyopathy or polyneuropathy with no obvious etiology
- •\- atypical Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) or Motor Neuron Disease (MND)
- •\- autonomic dysfunction
- •\- hypertrophic cardiomyopathy or heart failure with preserved ejection fraction Left Ventricular Hypertrophy (LVH)
- •\- bilateral carpal tunnel syndrome
- •\- spinal stenosis or spinal radiculopathy
Exclusion Criteria
- •Informed consent is not obtained from the participant
- •The participant is younger than 18 years of age
- •The participant has a diagnosis of alcoholism according to International guidelines
- •The participant has undergone chemotherapy for any carcinoma
- •The participant is not at risk for hATTR
Outcomes
Primary Outcomes
Not specified
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