Integrated Clinical-radiological Analysis of Hypoxia Markers in Pediatric Osteosarcomas - Single-center Pilot Study of 32 Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Retropsective study of pediatric osteosarcomas
研究概览
简要总结
The aim of this pilot study is therefore to retrospectively measure the volume and percentage of necrosis on diagnostic MRI in T1 sequence and in parallel to study the expression of immunohistochemical markers of hypoxia (HIF-1α, CAIX , HIF-2α, pS6, phosphomTor, CD163 and CD68) on diagnostic biopsies of high-grade osteosarcomas from 2007 to 2018 in the Strasbourg center, focusing on the pediatric population. The investigators will systematically carry out a correlation analysis between these different parameters and with the clinical data of these same patients (response to chemotherapy, presence of metastases or not and overall and recurrence-free survival). This will eventually make it possible to highlight new prognostic markers at diagnosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Year 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject ≤ 20 years at diagnosis
- •Subject having been treated for osteosarcoma in the OS2006 protocol or treated according to
- •Supported at Strasbourg University Hospitals between 05/01/2007 and 10/31/2018
- •Availability of its diagnostic tumor material stored in paraffin
- •having an MRI diagnostic evaluation comprising the injected T1 sequences necessary for the analysis of the volume / necrotic proportion.
排除标准
- •Opposition of the patient (or his legal representatives if he is a minor) to participate in the study
- •Diagnosis other than osteosarcoma
- •Biological tissue from a patient who does not meet all the inclusion criteria
- •Patient under legal protection
- •Patient under guardianship or guardianship
结局指标
主要结局
Retropsective study of pediatric osteosarcomas
时间窗: Files analysed retrospectively from January 01, 2007 to December 31, 2018 will be examined]
次要结局
未报告次要终点