NGAL Predictive Value of Acute Kidney Failure After Cardiac Surgery in Patients With Preoperative Chronic Kidney Failure

• Conditions: Preoperative KIDNEY FAILURE, CHRONIC; Postoperative KIDNEY FAILURE, ACUTE; Cardiac Surgical Procedures

• Registration Number: NCT01227122
• Lead Sponsor: Hopital Jean Minjoz

Brief Summary

Primary endpoint: To evaluate predictive value of plasmatic levels of Neutrophil Gelatinase Associated Lipocalin (NGAL) to reveal acute kidney failure after cardiac surgery in patients with preoperative chronic kidney failure Secondary endpoint is to obtain threshold values of NGAL.

Detailed Description

(N/A)

Study Timeline

• Study Start: 2010-08
• Study First Submitted: 2010-10-22
• Study First Submitted QC: 2010-10-22
• Study First Posted: 2010-10-25
• Status Verified: 2013-03
• Last Update Submitted: 2013-03-01
• Last Update Posted: 2013-03-04
• Primary Completion: 2013-07
• Study Completion: 2013-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Renal clearance less than 60 mL/min
• Able to give written consent
• Elective valve surgery
• Elective CABG surgery

Exclusion Criteria

• Less than 18 years old
• Iodine injection within 3 days before surgery
• Iodine injection within 24 first postoperative hours
• preoperative infection
• evolutive cancer disease
• Refusal
• Pregnancy
• Unable to give written consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Neutrophil Gelatinase Associated Lipocalin (NGAL) level	From surgery to discharge from hospital

Trial Locations

Locations (1)

Centre hospitalier Universitaire (CHU) Jean Minjoz; 🇫🇷 Besançon, Franche-Comté, France