The effect of L-glutamine on oral mucositis induced by chemoradiotherapy in patients with head and neck cancer.
Not Applicable
- Conditions
- Head and neck cancer.
- Registration Number
- JPRN-UMIN000024045
- Lead Sponsor
- Shiga University of Medical Science Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
1)Unable intake glutamine formulations per oral or per enteral tube. 2)major impairment of liver 3)major impairment of kidney 4)allergic to L-glutamine 5)pregnant,lactating 6)presence of other cancer under treatment. 7)severe psychosis or psychiatric symptoms 8)paticipation judged by physician to be inadvisable 9)paticipation not taking opioids
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CTCAE score for inflammation of oral pharyngeal mucosa.
- Secondary Outcome Measures
Name Time Method 1)Physical measurement Body weight, Lean body weight, body fat mass, Grip strength 2)Digestive symptom oral mucositis, taste disturbance, diarrhea, appetite 3)score of Quality of life(QOL) EORT-QLQ-C30 4)Blood test Alb,TP,PA,RBP,serum diamine oxidase activity,IL-6,active ghrelin 5)Amount of total Energy by oral feeding, enteral feeding, parenteral nutrition 6)Duration and dosage of opioid. 7)Rate of CRT completion.