Department of Anestheia and Intensive Care Unit,Cairo University
Overview
- Phase
- Early Phase 1
- Intervention
- Massimo device
- Conditions
- Controlled Hypotension for Nasal Surgeries
- Sponsor
- Cairo University
- Enrollment
- 40
- Primary Endpoint
- perfusion index
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Controlled hypotension has been used as a mean of reducing intraoperative blood loss and better visualization of the surgical field in nasal surgeries. Perfusion index has been considered a useful tool for monitoring changes in peripheral perfusion using Masimo set and serum lactate for central perfusion. Many medications were used to induce hypotension. In this study we will compare the effects of tridil and labetalol on the perfusion.
Detailed Description
The purpose of this study to detect the degree of hypotension that helps the surgeon and dosen't impair patient's perfusion and to compare the hypotensive effects of both tridil and labetalol infusions on the perfusion.
Investigators
Amany Hassan Saleh
department of anesthesia and intensive care unit,Cairo university
Cairo University
Eligibility Criteria
Inclusion Criteria
- •ASA I-II males and females aged 18-45 years who were scheduled for Functional Endoscopic sinus surgery (FESS)
Exclusion Criteria
- •uncontrolled hypertension, cerebrovascular disorders, bleeding and coagulation disorders, coronary artery diseases, renal or hepatic diseases or known hypersensitivity to the drugs used and pregnant.
Arms & Interventions
nitroglycerin group
this group will receive nitroglycerin infusion for controlled hypotension.0.5-5ug/kg/min to keep MAP 55-65mmhg then Massimo device will be attached to the patients when MAP reached the desired level
Intervention: Massimo device
nitroglycerin group
this group will receive nitroglycerin infusion for controlled hypotension.0.5-5ug/kg/min to keep MAP 55-65mmhg then Massimo device will be attached to the patients when MAP reached the desired level
Intervention: Nitroglycerin drug
labetalol group
this group will receive labetalol infusion fo controlled hypotension 0.4-3mg/kg/hr to keep MAP 55-65mmhg.then Massimo device will be attached to the patients when MAP reached the desired level
Intervention: Massimo device
labetalol group
this group will receive labetalol infusion fo controlled hypotension 0.4-3mg/kg/hr to keep MAP 55-65mmhg.then Massimo device will be attached to the patients when MAP reached the desired level
Intervention: Labetalol
Outcomes
Primary Outcomes
perfusion index
Time Frame: 3hrs
perfusion index is an indication of peripheral perfusion
serum lactate level
Time Frame: 3hrs
lactate level is an indication of central perfusion
Secondary Outcomes
- surgical feild score(3hrs)