Comparison between two drugs etomidate and propofol used to provide unconsciousness during general anaesthesia in elderly populatio
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2020/09/028003
- Lead Sponsor
- Dr Avanish Bhandary
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Individuals aged 60 years and above undergoing elective non cardiac surgeries requiring general anaesthesia with endotracheal intubation
2. American society of anaesthesiologist physical status 1, 2 and 3
Exclusion Criteria
1. Known allergy to propofol/etomidate
2. Anticipated difficult airway
3. Known primary and secondary adrenal insufficiency
4. Individuals on steroid medications in the past 6 months
5. History of seizure disorder
6. Patient refusal
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To compare change in SBP, DBP, HR and MAP following induction of anaesthesia in elderly with propofol and etomidate, up to 10 mins post intubation. <br/ ><br>2. To find a better inducing agent with respect to haemodynamic stability in elderlyTimepoint: Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure, SpOâ??, respiratory rate will be recorded a baseline value after connecting the monitors, after induction, just before and after laryngoscopy and intubation, at 1, 3, 5, 10 minutes post intubation. <br/ ><br>
- Secondary Outcome Measures
Name Time Method To determine the proportion of undesired effects of propofol and etomidate perioperatively such as pain on injection and myoclonus. <br/ ><br>Timepoint: a) Pain during injection will also be noted using 3 points graded scale <br/ ><br>0 â?? No pain <br/ ><br>1 â?? Slight pain <br/ ><br>2 â?? Moderate pain <br/ ><br>3 â?? Severe pain <br/ ><br> <br/ ><br>b) Myoclonic movements will be observed at least for 3 minutes after giving the drug and graded as <br/ ><br>0- No Myoclonic movements <br/ ><br>1- Mild myoclonus <br/ ><br>2- Moderate myoclonus <br/ ><br>3- Severe myoclonus