NCT01934569已完成1 期
Evaluation Of The Effect Of PF-05089771 On The Metabolism Of Multiple Cytochrome P450 And OATP1B1 Transporter Substrates
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Pfizer
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast)
研究概览
简要总结
This study will test the potential for PF-05089771 to interact with a cocktail of drugs
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male and/or female subjects between the ages of 18 and 55 years;
- •Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs);
排除标准
- •Any condition possibly affecting drug absorption
- •History of regular alcohol consumption
- •Screening supine blood pressure >140 mm Hg (systolic) or >90 mm Hg (diastolic),
- •Consumption of coffee, cola or other caffeine containing drinks
研究组 & 干预措施
Active tratment
Experimental
Pravastatin, midazolam, losartan, omeprazole, caffeine single dose alone or in combination with PF-05089771
干预措施: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771 (Drug)
结局指标
主要结局
Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast)
时间窗: 24h
Area under the plasma concentration time-curve from zero to the last measured concentration (AUClast)
Maximum Observed Plasma Concentration (Cmax)
时间窗: 24h
Minimum Observed Plasma Trough Concentration (Cmin)
时间窗: 24h
Time to Reach Maximum Observed Plasma Concentration (Tmax)
时间窗: 24h
次要结局
- Change from Baseline in Lipid Parameters(14 days)
研究者
研究点 (1)
Loading locations...
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