Booster Dose of Human Chorionic Gonadotrophin for Unruptured Follicle in Non IVF/ICSI Cycles: A Randomized Controlled Study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Ovulation rate
研究概览
简要总结
This study will be conducted to assess the effect of booster dose of hCG on the unruptured follicles in non IVF/ICSI cycles.
详细描述
In this study enrolled patients (n=160) who underwent controlled ovarian stimulation and timed intercourse with unruptured mature graffian follicle 48 hours after IM 10,000 IU HCG dose. Patients were allocated randomly into intervention group and control group. In the intervention group another booster dose (10,000 IU of hCG) was given IM while in the control group 2 ml normal saline was given IM leaving follicles for spontaneous rupture
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Double blinded
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Ordinary stimulated cycles
- •IUI stimulated cycles
- •Unruptured follicle after 10000 IU IM HCG triggering
排除标准
- •IVF/ICSI cycles
研究组 & 干预措施
Study group
HCG IM 10,000 IU Im 48 hours after first triggering dose
干预措施: hCG (Drug)
Control group
Saline 2m Injection im 48 hours after the first triggering dose
干预措施: Saline Solution (Drug)
结局指标
主要结局
Ovulation rate
时间窗: 48 hours
rupture of dominant follicle manifested by disappearance of follicle and presence of free fluid in douglas pouch
次要结局
- Pregnancy rate(15 days)
研究者
Ayman S Dawood, MD
Lecturer
Tanta University