The effect of ingesting a novel fortified plant-based protein mix on acute muscle protein synthesis in older people.

Recruiting

• Conditions: muscle anabolism; Muscle growth; 10028302

• Registration Number: NL-OMON53419
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

Male sex
Aged between 60 and 85 y inclusive
BMI between 18.5 and 35 kg/m2

Exclusion Criteria

Vegan/vegetarian diet
Intolerant to milk products
Soy allergy
Pea allergy
Participating in a structured (progressive) exercise program
Smoking regularly (i.e. >5 cigarettes/week)
Diagnosed GI tract disorders or diseases
Diagnosed musculoskeletal disorders
Diagnosed metabolic disorders (e.g. diabetes)
Diagnosed with phenylketonuria (PKU)
Uncontrolled hypertension (blood pressure above 160/100 mmHg)
Donated blood 3 months prior to test day
Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories).
Chronic use of gastric acid suppressing medication
Chronic use of anti-coagulants
Recent (<1 year) participation in amino acid tracer studies
(L-[ring-13C6]-phenylalanine and L-[3,5-2H2]-tyrosine)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>4-hour postprandial muscle protein synthesis rates in rest</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma amino acid concentrations<br /><br>Plasma glucose/insulin concentrations<br /><br>Relevant signalling pathways<br /><br>Gastrointestinal-palatability scores</p><br>