The effect of Mirabegron on brown adipose tissue in healthy young white Caucasian and South Asian me
- Conditions
- dyslipidemiaObesity10013317
- Registration Number
- NL-OMON46185
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 23
* Male volunteers. 10 white Caucasians, born in the Netherlands. 10 South Asians, living in the Netherlands.
* Age: 18-30 years
* BMI * 25 kg/m2;For the patients the inclusion criteria are:
- Male or female
- Age: 20-50 years
- BMI 18-40 kg/m2
- Hetro- of homozygote mutation in LPL or high density lipoprotein-binding protein 1 (HDL-binding protein 1))
* BMI > 25 kg/m2
* Recent excessive weight loss or exercise
* Alcohol and/ or drugs abuse
* Excessive smoking (>10 cigarettes/dag)
* Any significant chronic disease, including diabetes, Renal, hepatic or endocrine disease
* Heart disease or arrhythmias
* Thyroid disease or thyroid medication
* Hypertension
* Use of medication known to influence glucose and/or lipid metabolism or BAT activity (e.g. beta blockers or calcium channel blockers)
* Use of drugs that influence cardiac function or affect QT time
* Use of MAO inhibitor
* Use of systemic corticosteroids in previous six weeks
* Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
* Contraindications for undergoing an MRI scan.;For the patients the exclusion criteria are:
* Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
* Contraindications for undergoing an MRI scan.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Brown sadipose tissue activity as measured with the MRI scan.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Resting energy expenditure, changes in supraclaviclair skintemperature,<br /><br>parameters of glucose and lipid metabolisme and sympathic activation.</p><br>