The effect of exercise and nutrition on structural and functional systems in the elderly brai

Not Applicable

Completed

• Conditions: People over 65 years, healthy (self-report), and living independently or in a community residence; Not Applicable

• Registration Number: ISRCTN12084831
• Lead Sponsor: Swiss Federal Institute of Technology Zurich (ETH) (Switzerland)

Brief Summary

2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30866834 results (added 26/03/2019) 2016 Protocol article in https://pubmed.ncbi.nlm.nih.gov/27965570/ (added 10/01/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-12-01
• Study Completion: 2016-12-31
• Last Update Posted: 23 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Age above 65 years
2. Live independently or in a residency dwelling
3. Non-smoker
4. Healthy (self-reported)

Exclusion Criteria

1. Mobility or cognitive impairments
2. Orthopaedic or neurological diseases preventing training participation
3. Rapidly progressive or terminal illness, acute or chronic illness
4. History of stroke, epilepsy, or seizure
5. Medication that interacts with nutritional supplementation
6. Medication that acts on a neuronal level
7. Mini Mental Status < 22 points
8. Signs of upcoming depression (GDS)
9. Electronic or metallic head implants

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Current primary outcome measures as of 24/02/2016:<br>1. Structural level:<br>1.1. Transcranial magnetic stimulation: Motor evoked potential in M.tibialis anterior <br>2. Functional level:<br>2.1. Electroencephalography: Event related potential and frequency band distribution <br>2.2. Cognitive test: Test for Attentional Performance (TAP)<br>All measures are assessed pre-intervention and after intervention.<br><br>Previous primary outcome measures:<br>1. Structural level:<br>1.1. Transcranial magnetic stimulation: Motor evoked potential in M.tibialis anterior <br>2. Functional level:<br>2.1. Electroencephalography: Event related potential and frequency band distribution <br>2.2. Cognitive tests: Test for Attentional Performance (TAP) and Attention Network Test (ANT)<br>All measures are assessed pre-intervention and after intervention.

Secondary Outcome Measures

Name	Time	Method
1. Gait parameters:<br>1.1. Temporal and spatial gait parameters are assessed with the Physilog®<br>2. Prevention of falls:<br>2.1. Icon Falls Efficacy Scale International (Icon-FES-I) questionnaire is used as a measure of 'concern' about falling, to determine the transfer effects of training to activities of daily living<br>3. Mental state and depression:<br>3.1. Mini Mental State Examination (MMSE)<br>3.2. Geriatric Depression Scale (GDS): symptoms of depression are recorded. The German version of the GDS has a good validity and reliability<br>4. Blood samples measuring fatty acid<br><br>All measures are assessed pre-intervention and after intervention. In addition, blood samples are measured after 16 weeks.