Short Term Surgical Outcomes of Anatomical Versus Non Anatomical Laparoscopic Liver Resection for Liver Tumors

• Conditions: Liver Neoplasms
• Interventions: Procedure: Non-Anatomical laparoscopic liver resection for liver neoplasms; Procedure: Anatomical laparoscopic liver resection for liver neoplasms

• Registration Number: NCT06271109
• Lead Sponsor: Sohag University

Brief Summary

aimed to discuss the short term surgical outcomes of Anatomical versus Non anatomical laparoscopic Liver resection for Liver tumors.

Detailed Description

This study aimed to be both prospective and retrospective study including the cases of laparoscopic liver resection that was done and will be done during the period from December 2021 to June 2025. This study will include cohort of patients who met the eligible criteria.

Complete history taking with special concern to the following:

* Age, sex and life style.

* present medical history: hepatic condition and other debilitating diseases.

* Past medical History: blood transfusion, hepatitis, liver cirrhosis and history of hospital admission.

Complete local examination of the abdomen including:

* Local examination of the skin overlying for any signs of infection, radiation fibrosis and or presence of sinuses

* Percussion for presence of ascites

* Palpation for cirrhosis or any palpable masses investigations will be carried

1. Ultrasonography: routine abdominal US for every case.

2. Triphasic CT scan

3. CT volumetric study to evaluate remaining liver volume when needed.

4. Dynamic or triphasic MRI if needed

5. Metastatic work up (CT chest, bone scan and PET scan in selected patients).

6. Preoperative histopathological examination when needed.

7. routine laboratory investigations

Study Timeline

• Study Start: 2021-12-01
• Status Verified: 2024-02
• Study First Submitted: 2024-02-05
• Study First Submitted QC: 2024-02-14
• Last Update Submitted: 2024-02-14
• Study First Posted: 2024-02-21
• Last Update Posted: 2024-02-21
• Primary Completion: 2025-06-01
• Study Completion: 2025-06-01

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• all patients diagnosed with liver tumors (benign and malignant) lesions suitable for laparoscopic liver resection (Anatomical and Non anatomical)
• Patients with Child Pugh A and early B
• Patients Fit for surgery as regard anesthesia
• Patients who accept to participate in the study and sign an informed consent

Exclusion Criteria

• Patients with Child Pugh late B&C liver disease.
• For Patients with hepatocellular carcinoma BCLC stage C&D (extra hepatic spread and macro vascular invasion)
• Patients with contraindications to laparoscopic surgery and (or) unfit for surgery.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
laparoscopic Non Anatomical liver resection	Non-Anatomical laparoscopic liver resection for liver neoplasms	-
laparoscopic Anatomical liver resection	Anatomical laparoscopic liver resection for liver neoplasms	-

Primary Outcome Measures

Name	Time	Method
complete resection of the neoplasm	3.5 years	to ensure complete resection with free resection margins

Secondary Outcome Measures

Name	Time	Method
residual liver tissue	3.5 years	to evaluate the remnant liver tissue post neoplasm resection
recurrence rate	3.5 years

Trial Locations

Locations (1)

Sohag University; 🇪🇬 Sohag, Egypt