efficacy of Dexmedetomidine and metoral on reducing hemorrhage during craniotomy

Phase 2

Recruiting

• Conditions: Craniotomy.; S08.89; Traumatic amputation of other parts of head

• Registration Number: IRCT20190417043302N1
• Lead Sponsor: Arak University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 May 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

Patients with head trauma
Patients with ASA class I and II
Patients that the informed written consent form has been fillede out by their legal gurdian in order to participate in the study
Candidates of craniotomy due to severe head trauma
Patients with severe head trauma candidates of craniotomy with a maximum operation duration of 150 min
Patients with severe head trauma candidates of craniotomy that are operated by a neurosurgeon
Patients with severe head trauma candidates of craniotomy aged between 15-75 years

Exclusion Criteria

Patients with severe head trauma candidates of craniotomy which have hypersensitivy to dexmedetomidine and metoprolol
Patients with severe head trauma candidates of craniotomy that their legal gurdian refuse the informed written consent for participation in the study.
Patients with a past medical history of cardio-vascvular diseases, uncontrolled diabetes, seizure and epilepsy, renal failure, liver failure, coagulation disorders, previous cerebrovascular accident or recent myocardial infarction

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bleeding. Timepoint: Every 15 minutes to end of surgery. Method of measurement: Observation.;Mortality. Timepoint: After surgery. Method of measurement: observation.