Influence of coenzyme Q10 on periodontal inflammation - a randomized controlled trial

Dr. med. Schütze GmbH0 个研究点目标入组 50 人开始时间: 2020年10月30日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•gender male or female, age between 40 and 70 years
•ability to give informed consent
•voluntary participation
•caries-free, sufficently treated teeth (D-T = 0)
•generalized periodontitis stage III-IV
•periodontal treatment need according to periodontal chart
•at least 20 remaining teeth
•BOP = 30%, PD = 5mm at = 35% of the probing sites
•pretreatment: 2 professional teeth cleaning with an interval of 2-3 weeks before the periodontal chart

•planned adjuvant antibiotic treatment in the periodontal treatment
•less than 20 remaining teeth
•BOP < 30 %
•last systematic scaling and root planing in the last 24 months
•antibacterial, anti-inflammatory or immunosuppressive medication in the last 3 months before and during the study
•local antiseptic or antibacterial treatment in the last 4 weeks before and during the study
•known intolerance against ingredients of the used spray, toothpaste or other in the study used materials
•patients with significantly reduced / missing fine motor skills
•not feasible investigation due to poor general condition
•patients with significantly reduced salivation/ xerostomia
•patients with dementia
•immunosuppressed patients: transplanted organs, autoimmune disease (e.g. chronical intestine diseases, rheumatoid arthritis
•hepatitis A/B/C, tuberculosis, HIV (upon request)
•diabetes mellitus
•participants that would need an antibiotic prophylaxis (e.g. risc for endocarditis, immunosuppression)
•participants with epileptic or neurological disorders
•pregnant or nursing women (upon request)

发起方

Dr. med. Schütze GmbH