utritional response to chyme reinfusion therapy in intestinal failure – a pilot study
Not Applicable
- Conditions
- Intestinal failureMalabsorptionMalnutritionDiet and Nutrition - Other diet and nutrition disordersOral and Gastrointestinal - Normal oral and gastrointestinal development and function
- Registration Number
- ACTRN12623001254684
- Lead Sponsor
- Massey University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Adult patients with type 2 intestinal failure and suitability for chyme reinfusion therapy (CRT) (double enterostomy, entero-atmospheric fistula (EAF) or proximal ileostomy with an accessible distal limb), and younger than 70 years.
Exclusion Criteria
Patients who have an anastomotic leak or bowel obstruction, or are pregnant, immunocompromised, or unable to understand risks and benefits.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantify relative dietary protein digestibility relative to basal state and healthy people using stable isotope tracer technique.[ Healthy participants - during one-off visit, <br>T2IF Participants - immediately before receiving CRT and 3 weeks after receiving CRT.];Investigate the change in whole-body short chain fatty acid (SCFA) production (derived from colonic) relative to basal state and healthy people using stable isotope tracer technique.[ Healthy participants - during one-off visit, <br>T2IF Participants - immediately before receiving CRT and 3 weeks after receiving CRT.];Explore the patient experience of CRT and stable isotope tracer protocol qualitatively before, during and after treatment of T2IF using semi-structured interviews.[ Three times - Before commencing CRT, during the study after Day 1 of Investigation and 3 weeks after receiving CRT.]
- Secondary Outcome Measures
Name Time Method