Physiological Response to 5 Days Fasting
- Conditions
- Healthy
- Interventions
- Other: Buchinger fasting
- Registration Number
- NCT04452916
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
To investigate energy metabolism, anthropometry, blood pressure, gut microbiome, serum metabolome, glucose variability and neural mechanisms of food choice and mood before and after 5 days of fasting as well as their persistence in healthy men and women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 55
- Men and women
- 20-50 years
- Body mass index 20-30 kg/m2
- Clinically relevant heart, lung, liver, and kidney diseases
- Any prescribed medication (except for oral contraceptives)
- Current or chronic infection
- Intake of antibiotics within 6 months before study entry
- Fasting week within 6 months before study entry
- Habitual use of dietary supplements
- Food intolerances
- Pregnancy, lactation
- Vegan diet
- Smokers
- In addition for fMRI: sensorineural hearing loss, tinnitus, metal implants, electric devices
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fasting Buchinger fasting Starts immediately with 5 days of Buchinger fasting Waiting list control Buchinger fasting Starts with 5 days of Buchinger fasting after a waiting period of 12 weeks
- Primary Outcome Measures
Name Time Method Resting Energy Expenditure 6-th day of fasting compared to baseline Measured by indirect calorimetry (kcal/d)
- Secondary Outcome Measures
Name Time Method Fecal microbiome composition 6-th day of fasting and 12 weeks after fasting compared to baseline Measured by 16S Sequencing
Office systolic blood pressure 6-th day of fasting and 12 weeks after fasting compared to baseline Mean of five consecutive blood pressure measurements (mmHg)
Resting Energy Expenditure - Recovery 12 weeks after fasting compared to baseline Measured by indirect calorimetry (kcal/d)
Glucose variability From 3 days before until 6 days after fasting Measured by continuous glucose monitoring over 14 days
Office diastolic blood pressure 6-th day of fasting and 12 weeks after fasting compared to baseline Mean of five consecutive blood pressure measurements (mmHg)
Resting Respiratory Exchange Ratio 6-th day of fasting and 28 days after fasting compared to baseline Measured by indirect calorimetry
Fecal and serum metabolome 6-th day of fasting and 12 weeks after fasting compared to baseline Measured by mass spectrometry
Neural correlates of emotion processing 6-th day of fasting and 12 weeks after fasting compared to baseline Measured by functional Magnetic Resonance Imaging
Perceived Stress Questionaire (PSQ) 6-th day of fasting and 12 weeks after fasting compared to baseline Range 0-100, with 0 indicating no perceived stress
International Physical Activity Questionaire (IPAQ, long version) 6-th day of fasting and 12 weeks after fasting compared to baseline Time for moderate and vigorous activity (hours, minutes)
Change in immune cell phenotypes 6-th day of fasting and 12 weeks after fasting compared to baseline Peripheral blood effector T cell frequencies (Percent)
Neural correlates of food-specific delay discounting 6-th day of fasting and 12 weeks after fasting compared to baseline Measured by functional Magnetic Resonance Imaging
Perceived Self Efficiency 6-th day of fasting and 12 weeks after fasting compared to baseline Range 10-40, with 40 indicating highest self efficiency
PANAS Positive Affect Subscale (GESIS Panel) 6-th day of fasting and 12 weeks after fasting compared to baseline Range 10-50, with 50 indicating highest positive affect
PANAS Negative Affect Subscale (GESIS Panel) 6-th day of fasting and 12 weeks after fasting compared to baseline Range 10-50, with 50 indicating highest negative affect
Trial Locations
- Locations (1)
Charité Universitätsmedizin Berlin
🇩🇪Berlin, Germany