Assessing the Effect of Diet on Hypothalamic Gliosis in Humans

University of Washington1 site in 1 country36 target enrollmentJanuary 13, 2023

ConditionsGliosis Obesity Eating

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Gliosis
Sponsor: University of Washington
Enrollment: 36
Locations: 1
Primary Endpoint: Hypothalamic Gliosis
Status: Completed
Last Updated: 8 months ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to use magnetic resonance imaging (MRI) to evaluate the human hypothalamus for signs of inflammation in response to specific diets. This research may lead to a better understanding of how poor nutritional quality may lead to obesity through effects on regions of the brain known to regulate body weight.

Registry

clinicaltrials.gov

Start Date

January 13, 2023

End Date

June 30, 2025

Last Updated

8 months ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Washington

Responsible Party

Principal Investigator

Ellen Schur, MD, MS

Professor, School of Medicine

University of Washington

Eligibility Criteria

Inclusion Criteria

•Age 20-40 years
•Overweight: BMI 25-29.9 kg/m2
•Willing to undergo randomly assigned 14-day diet modification

Exclusion Criteria

•History of bariatric surgery or active participation in weight-loss program
•Major medical or neurological disorder (e.g., diabetes, multiple sclerosis)
•Anemia or impaired kidney or liver function
•Known gallbladder disease or gallstones
•Hypertriglyceridemia (\>350 mg/dl)
•Current use of orlistat or other weight-loss medications or other medications known to alter appetite (e.g., atypical anti-psychotics)
•More than moderate level of physical activity (\>1000 met-min/wk)
•Pregnancy, menopause, or breastfeeding
•MRI contraindication (e.g., implanted metal, claustrophobia)
•Lifetime eating disorder