The effects of nasal continuous positive airway pressure on cardiac function in (i) premature infants with established lung disease and (ii) premature infants with minimal lung disease.

Not Applicable

Completed

• Conditions: effect of nasal CPAP on right ventricular output; in premature infants with significant lung disease and minimal lung disease; Cardiovascular - Normal development and function of the cardiovascular system; Reproductive Health and Childbirth - Complications of newborn; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12611001057976
• Lead Sponsor: Royal Women's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-10-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

Premature infants with a corrected gestational age of 28-34 weeks, admitted to the Neonatal Intensive and Special Care and treated with nasal CPAP.

Exclusion Criteria

Infants with sepsis, organ failure, necrotizing enterocolitis, seizures, or identified by the clinical team to be too sick to participate in the study will be excluded.
Infants will be excluded if they have congenital heart disease including a haemodynamically significant patent ductus arteriosus (PDA), atrial septal defect (ASD)/persistent foramen ovale (PFO) and/or ventricular septal defect (VSD). Infants will also be excluded if they are treated with fractional inspired oxygen (FiO2) of more than 40%, and/or treated with a PEEP higher than 7 cmH2O, or nasal intermittent mandatory ventilation (nIMV).

Study & Design

• Study Type: Interventional
• Study Design: Not specified