sing genotype to tailor prescribing of Nicotine Replacement Therapy (NRT): a randomised controlled trial assessing impact upon medication adherence

Not Applicable

Completed

• Conditions: Smoking; Mental and Behavioural Disorders; Smoking addiction

• Registration Number: ISRCTN14352545
• Lead Sponsor: King's College London (UK)

Brief Summary

1. 2010 protocol in http://www.ncbi.nlm.nih.gov/pubmed/21062464 2. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22509402 3. 2013 results in http://ntr.oxfordjournals.org/content/early/2013/02/18/ntr.ntt010.abstract 4. 2018 results in https://www.ncbi.nlm.nih.gov/pubmed/29385578

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-05-17
• Study Completion: 2009-05-21
• Last Update Posted: 26 February 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 630

Inclusion Criteria

Eligible participants are:
1. Motivated quitters attending the participating NHS smoking cessation clinics
2. Participants must be smokers smoking 10 or more cigarettes per day over the last 12 months
3. Aged 18 and over
4. Living in the British Isles

Exclusion Criteria

1. Non-smokers
2. Smokers smoking less than 10 cigarettes daily over the last 12 months
3. Aged under 18
4. Living outside the British Isles
5. Cigar/pipe smokers
6. NRT contraindications (e.g. pregnant or lactating women)
7. Those with previous severe adverse reactions to NRT
8. Currently taking medication for smoking cessation that they are unwilling to cease taking or medication with a known influence on smoking cessation that they cannot stop

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The proportion of all NRT consumed in the first 4 weeks of quitting or to the point of relapse, whichever is the sooner. This will be measured by self-report daily diary, backed up by 'pill count reconciliation' with the diary at the clinic. If pill counts are discrepant with the diary, this will be discussed and reconciled at the clinic visit.

Secondary Outcome Measures

Name	Time	Method
1. Responses to the Mood and Physical Symptoms Scale, a measure of nicotine withdrawal symptoms<br>2. Point prevalance of 14-day complete abstinence measured at 28 days after smoking cessation<br>3. Response efficacy of NRT<br>4. State anxiety