Evaluation of Corneal Endothelium Following Phacoemulsification in Diabetic and Non-diabetic Patients With Pseudoexfoliation Syndrome by Specular Microscopy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pseudoexfoliation
- Sponsor
- Minia University
- Enrollment
- 61
- Locations
- 1
- Primary Endpoint
- coefficient of variation (CV)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Our study is a comparative study, that was conducted to evaluate the corneal endothelial cells changes and central corneal thickness after uncomplicated phacoemulsification and intra ocular lens (IOL) implantation in normal controls, in non-diabetic and diabetic patients with PEX, and in patients with PEX only using specular microscopy.
Detailed Description
Our study is a comparative study that included 4 groups (controls, patients with PEX, non-diabetic patients with PEX, diabetic patients with PEX) to evaluate the corneal endothelial cells changes and central corneal thickness after uncomplicated phacoemulsification and intra ocular lens (IOL) implantation using specular microscopy, over a 6 months follow up period.
Investigators
Heba Radi AttaAllah
Associate Professor of Ophthalmology
Minia University
Eligibility Criteria
Inclusion Criteria
- •Senile cataract with age between 50 to 70 years
- •Clear cornea with no zonuler dehiscence
- •Lens opacity classification system III (LOCS III), with grade 2-3 nuclear cataract with any additional cortical (C) and posterior sub capsular (P)
Exclusion Criteria
- •Uncontrolled DM in diabetic groups
- •Presence of autoimmune diseases
- •Patients with glaucoma
- •Corneal guttata
- •Zonular dehiscence
- •Rupture posterior capsule during cataract surgery
Outcomes
Primary Outcomes
coefficient of variation (CV)
Time Frame: 6 months
indicator of the uniformity of the size of endothelial cells
Percentage of hexagonal cells
Time Frame: 6 months
indicator of healthy endothelial cells
Central corneal thickness
Time Frame: 6 months
measurement of the distance between the epithelium and endothelium at the central cornea
endothelial cell density
Time Frame: 6 months
number of endothelial cells