Magnetic Resonance Imaging (MRI) Sequences Optimization in Healthy Subjects

Not Applicable

Completed

• Conditions: Healthy Volunteers

• Registration Number: NCT02900339
• Lead Sponsor: Rennes University Hospital

Brief Summary

Magnetic resonance imaging (MRI) is a noninvasive and non-ionizing (no use of X-rays) imaging modality. Today it is considered an anatomical and functional exploration reference technique. Since its inception around 1985, this technology is constantly evolving.

Many advances in MRI require constant adaptations of radiological practices. The morphological image is now associated with functional and parametric information (infusion, diffusion spectroscopy, etc ...). In parallel, work combining acquisition and post-processing of data also open new applications (tractography, functional MRI, etc ....). Thus, more and more procedures are necessary to "integrate" these techniques for the diagnosis and adapt to new demands of clinicians.

The type of sequence and its associated parameters allow to directly influence the contrast of images, to characterize tissue compared to another and, ultimately, to highlight morphological or functional abnormality. Image quality can be optimized on each MRI, depending on the time available for the acquisition on the one hand, and on the desired resolution and contrast, on the other hand. For each sequence, it is therefore necessary to find a compromise that will optimize the diagnostic quality of the examination.

This optimization requires a phase focusing on healthy volunteers. It is therefore important that researchers and physicists could design on healthy volunteers, the best settings of all parameters for an image or spectrum. Indeed, it is always necessary to properly optimize every parameter choices before beginning a study of a cohort of patients.

In this context, the main objective of this study is to optimize sequences and imaging protocols to evaluate and validate the choice of parameters in healthy volunteers.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04-18
• Study First Submitted: 2016-09-09
• Study First Submitted QC: 2016-09-09
• Study First Posted: 2016-09-14
• Primary Completion: 2021-10-12
• Study Completion: 2021-10-12
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-13
• Last Update Posted: 2022-12-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 628

Inclusion Criteria

• Men or women aged over 18 years
• Written informed consent given

Exclusion Criteria

• contraindication to MRI :

  • Claustrophobia
  • morphotype not allowing access to MRI
  • Wear a metallic implant, such as:
  • Pacemaker (pacemaker)
  • Ferromagnetic surgical clips
  • Intra orbital metallic foreign bodies or encephalic

• Pregnancy

• Breastfeeding

• Adults under guardianship, trusteeship or safeguard justice

• No social Insurance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Quantitative assessment of acquired sequences	One day after data acquisitions	Quality images, maps or spectra acquired with optimized parameters will be compared to standard acquisitions.; This evaluation will be based on quantitative criteria extracted from computer analysis of the data : signal to noise ratio, contrast-to-noise, blur level, information sharing, collocation of areas set evidenced by the different techniques, etc...

Secondary Outcome Measures

Name	Time	Method
Qualitative assessment of acquired sequences	One day after data acquisitions	Quality images, maps or spectra acquired with optimized parameters will be compared to standard acquisitions.; This evaluation will be based on statistical comparison of visual qualitative criteria by experts radiologists

Trial Locations

Locations (1)

Radiology Department CHU de Rennes; 🇫🇷 Rennes cedex 9, France