Optimization of MRI for Radiation Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cancer Liver
- Sponsor
- University of Michigan Rogel Cancer Center
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- Percentage of participants with MRI images suitable for analyses
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients ≥18 years of age
- •A working diagnosis of malignancy in the liver, brain, H\&N, or pelvis
- •A plan to treat with radiotherapy
Exclusion Criteria
- •Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.
Outcomes
Primary Outcomes
Percentage of participants with MRI images suitable for analyses
Time Frame: Day One
Patients will be off protocol immediately after the single MRI scan. Comparative treatment planning will occur off-line and will not be used for patient care.