Current Situation of Natural History, Diagnosis and Treatment in Inpatients With Embolism Stroke of Unknown Cause (ESUS)

Completed

• Conditions: Embolic Stroke of Undetermined Source
• Interventions: Other: ESUS

• Registration Number: NCT04455529
• Lead Sponsor: Peking University Third Hospital

Brief Summary

Evaluate the epidemiological characteristics, risk factors, clinical characteristics in patients with ESUS and their medication compliance and relapse within 1 year.

Detailed Description

The purpose of this study is to evaluate the epidemiological characteristics, risk factors (such as hypertension, diabetes, hyperlipidemia, coronary heart disease, history of previous stroke, smoking, and alcohol consumption), clinical characteristics in patients with ESUS and their medication compliance and relapse within 1 year.

Study Timeline

• Study Start: 2016-09-01
• Primary Completion: 2017-09-01
• Study Completion: 2017-09-01
• Status Verified: 2020-06
• Study First Submitted: 2020-06-28
• Study First Submitted QC: 2020-07-01
• Last Update Submitted: 2020-07-01
• Study First Posted: 2020-07-02
• Last Update Posted: 2020-07-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Patients diagnosed with acute cerebral infarction and treated in Peking University Third Hospital Neurology Department from January 2010 to June 2016.

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Exclusion Criteria

• Lacunar infarction
• Aortic atherosclerotic cerebral infarction
• Clear cardiogenic cerebral infarction
• Other related system diseases (arteritis, vascular dissection, migraine and vasospasm, etc.)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ESUS	ESUS	Embolic stroke of undetermined source (ESUS) designates patients with nonlacunar cryptogenic ischemic strokes in whom embolism is the likely stroke mechanism.

Primary Outcome Measures

Name	Time	Method
Medication adherence	1 year after recruitment	Medication adherence usually refers to whether patients take their medications as prescribed (eg, twice daily), as well as whether they continue to take a prescribed medication. The Morisky scale, a validated, 4-item self-reported adherence measure that has been shown to be predictive of adherence to cardiovascular medications and blood pressure control. If a patient scores higher on the scale, they are evaluated as more adherent. If they score lower on the scale, they are presumed to be struggling with nonadherence.
Recurrence rate	1 year after recruitment	Recurrence rate of stroke