The Influence of Different Fluid Therapy Measures on the Postoperative Outcome in Fast Track of Colon Cancer After Laparoscopic Surgery.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 主要终点
- recovery time of intestinal function
研究概览
简要总结
To compare the influence of two different fluid administration strategies on the clinical efficacy of patients with colorectal carcinoma during the fast-track surgery.
详细描述
Patients that were diagnosed with colorectal carcinoma by the First Hospital of Jilin University and were scheduled to undergo the laparoscopic surgery were prospectively included and divided into the experimental group and the control group with the random number method. After surgery, patients in the experiment group were provided with intravenous fluid administration at 1.0ml/Kg/h and encouraged to take food and drink water early after surgery, and the intravenous fluid administration was stopped immediately when the oral intake was more than 1500ml/h; patients in the control group strictly followed the fasting and were provided with the intravenous fluid administration according to "Total amount of fluid = physiological requirement + additional loss (fever + gastrointestinal decompression) + amount lost" until their intestinal function completely recovered. The blood volume change indicators (heart rate, mean arterial pressure, oxyhemoglobin saturation, inferior vena cava diameter /body surface area (VCD), intra-abdominal pressure, specific gravity of urine, BNP, etc.) and inflammation indicators (CRP, IL-6, TNF-a) of the two groups of patients were observed and a comparison was made of the recovery time of intestinal function, incidence of complications, hospitalization time after operation and hospitalization expenses of the two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •the age of 18-70 years old
- •the pathological diagnosis of colon cancer patients
- •no surgical intervention.
排除标准
- •patients with heart, lung, liver, renal function were significantly abnormal
- •body mass index kg >35 / m2
- •sepsis or systemic inflammatory response syndrome patients.
- •patients with severe malnutrition.
结局指标
主要结局
recovery time of intestinal function
时间窗: within the first 30 days (plus or minus 3 days) after surgery
次要结局
- CRP[=C reactive protein]ba(the first day to the forth day After the operation)
- IL-10[=interleukin-10](the first day to the forth day After the operation)
- BNP[=type B natriuretic peptide](the first day to the forth day After the operation)
- hospitalization time after operation(day)(within the first 30 days (plus or minus 3 days) after surgery)
- TNF-alpha(the first day to the forth day After the operation)
研究者
Quan Wang
Deputy chief physician
The First Hospital of Jilin University
