Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia

Early Phase 1

• Conditions: Hypotension Drug-Induced
• Interventions: Drug: Lactated Ringer

• Registration Number: NCT03478618
• Lead Sponsor: Assiut University

Brief Summary

To compare the effect of two different protocol of fluid therapy in sever preeclamptic patients under spinal anesthesia : Hemodynamic and kidney function .

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-03
• Study Start: 2018-03
• Study First Submitted: 2018-03-21
• Study First Submitted QC: 2018-03-21
• Last Update Submitted: 2018-03-21
• Study First Posted: 2018-03-27
• Last Update Posted: 2018-03-27
• Primary Completion: 2019-03
• Study Completion: 2019-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• more than 36 weeks gestation
• singleton pregnant women planned for elective caesarian section

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Exclusion Criteria

• patient refusal.
• psychiatric disorders.
• parturient <36 weeks gestation, twins, abnormal cardiotocography (CTG) tracing.
• absolute contraindications for spinal anesthesia (patients refusal, raised intracranial pressure, hypovolemic states, abnormal coagulopathy).

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group R	Lactated Ringer	30 patients will receive 15ml/kg/h lactated Ringer (LR) intraoperative.
Group L	Lactated Ringer	30 patients will receive 30ml/kg/h lactated Ringer (LR) intraoperative.

Primary Outcome Measures

Name	Time	Method
incidence of hypotension	1 hour	decrease in systolic blood pressure more than 20% of base line