NCT03478618Unknown早期 1 期
Comparison of Two Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia : Hemodynamic and Kidney Function Outcome
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 入组人数
- 60
- 主要终点
- incidence of hypotension
研究概览
简要总结
To compare the effect of two different protocol of fluid therapy in sever preeclamptic patients under spinal anesthesia : Hemodynamic and kidney function .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •more than 36 weeks gestation
- •singleton pregnant women planned for elective caesarian section
排除标准
- •patient refusal.
- •psychiatric disorders.
- •parturient <36 weeks gestation, twins, abnormal cardiotocography (CTG) tracing.
- •absolute contraindications for spinal anesthesia (patients refusal, raised intracranial pressure, hypovolemic states, abnormal coagulopathy).
研究组 & 干预措施
Group R
Active Comparator
30 patients will receive 15ml/kg/h lactated Ringer (LR) intraoperative.
干预措施: Lactated Ringer (Drug)
Group L
Active Comparator
30 patients will receive 30ml/kg/h lactated Ringer (LR) intraoperative.
干预措施: Lactated Ringer (Drug)
结局指标
主要结局
incidence of hypotension
时间窗: 1 hour
decrease in systolic blood pressure more than 20% of base line
次要结局
未报告次要终点
研究者
Bola Fawzi Mekhail Sedrak
principal investigator
Assiut University
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