DRKS00015861
Completed
未知
Role of the immune system and the gut microbiota in neuroprotection: a dietary human intervention trial
Institut für Ernährungs- und Lebensmittelwissenschaften, Abteilung Ernährungsphysiologie, Rheinische Friedrich-Wilhelms-Universität Bonn0 sites120 target enrollmentJanuary 28, 2019
Conditionscardio metabolic risk
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- cardio metabolic risk
- Sponsor
- Institut für Ernährungs- und Lebensmittelwissenschaften, Abteilung Ernährungsphysiologie, Rheinische Friedrich-Wilhelms-Universität Bonn
- Enrollment
- 120
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Caucasian participants aged 45\-70 years
- •BMI 27\-39,9 kg/m²
- •at least one trait of the metabolic syndrome: (i) central obesity (waist circumference \= 94 cm for men and \= 80 cm for women); (ii) hypertension (\=140–159 mmHg SBP and/or \=90–99 mmHg DBP); (iii) dyslipidemia (fasting serum triglyceride concentrations \=1\.7 mmol/l and/or serum concentrations of HDL\-cholesterol \<1\.0 mmol/l for men and \<1\.3 mmol/l for women)
- •(IV) proinflammatory state (high\-sensitive C\-reactive protein \=2 mg/l)
- •Written declaration of consent to study participation
Exclusion Criteria
- •type 2 diabetes mellitus;
- •chronic liver, gastrointestinal, or in?ammatory disease (hs\-CRP \> 30 mg/L) including rheumatoid Arthritis
- •history of cardiovascular events;
- •untreated thyroid dysfunction;
- •recent major surgery or illness;
- •pregnancy or lactation;
- •alcohol, drug or medication use disorder;
- •regular consumption of dietary supplements notably n\-3 fatty acids, Vitamin E and/or Magnesium
- •vegetarians
- •food intolerance (fish)
Outcomes
Primary Outcomes
Not specified
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